Evidence map›Paper›PMID 33511457›Full record

ArticleAnalytical and bioanalytical chemistry2021

Development of a clinical assay to measure chlorinated tyrosine in hair and tissue samples using a mouse chlorine inhalation exposure model.

Brooke G Pantazides, Brian S Crow, Jennifer Quiñones-González, Jonas W Perez, Jill A Harvilchuck, Jeffrey J Wallery, Tom C Hu, Jerry D Thomas, Rudolph C Johnson, Thomas A Blake

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Verification of chlorine exposure via LC-MS/MS analysis of base hydrolyzed chlorophenols from chlorotyrosine-protein adducts.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Brooke G PantazidesEmergency Response Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA, 30341, USA.
Brian S CrowEmergency Response Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA, 30341, USA. jgz8@cdc.gov.
Jennifer Quiñones-GonzálezEmergency Response Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA, 30341, USA.
Jonas W PerezEmergency Response Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA, 30341, USA.
Jill A HarvilchuckBattelle Memorial Institute, 505 King Avenue, Columbus, OH, 43201, USA.
Jeffrey J WalleryBattelle Memorial Institute, 505 King Avenue, Columbus, OH, 43201, USA.
Tom C HuChemical Medical Countermeasures, Division of CBRN Countermeasures, Biomedical Advanced Research and Development Authority (BARDA), 330 Independence Ave, SW, Washington, DC, 20201, USA.
Jerry D ThomasEmergency Response Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA, 30341, USA.
Rudolph C JohnsonEmergency Response Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA, 30341, USA.
Thomas A BlakeEmergency Response Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA, 30341, USA.
National Center for Environmental Health · USCenters for Disease Control and Prevention · USBattelle · USBiomedical Advanced Research and Development Authority · US

Funding

Biomedical Advanced Research and Development Authority Task Order contract HHSO100201500004ICenters for Disease Control and Prevention and the Center for Preparedness and Response PID 14782Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Chlorine is a toxic industrial chemical with a history of use as a chemical weapon. Chlorine is also produced, stored, and transported in bulk making it a high-priority pulmonary threat in the USA. Due to the high reactivity of chlorine, few biomarkers exist to identify exposure in clinical and environmental samples. Our laboratory evaluates acute chlorine exposure in clinical samples by measuring 3-chlorotyrosine (Cl-Tyr) and 3,5-dichlorotyrosine (Cl

Indexed as

Inhalation ExposureAnimalsBiomarkersBronchoalveolar Lavage FluidCalibrationChlorineChromatographyDisease Models, AnimalHairLungMaleMiceMice, Inbred C57BLPlasmaQuality ControlTandem Mass Spectrometry3,5-dichlorotyrosine3-chlorotyrosineBiomarkersChlorineTyrosine3,5-Dichlorotyrosine3-ChlorotyrosineChlorine gasHair and lung tissueIn vivo mouse studyLC-MS/MS

Identifiers

PMID33511457
PMCPMC8042785
OpenAlexW3125611324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.