Evidence map›Paper›PMID 33511450›Full record

ArticlePsychopharmacology2021

Serotonin 5-HT

Kally C O'Reilly, Michelle Connor, Jamie Pierson, Lauren C Shuffrey, Randy D Blakely, Susanne E Ahmari, Jeremy Veenstra-VanderWeele

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Kally C O'ReillyDepartment of Psychiatry, New York State Psychiatric Institute, Columbia University, 1051 Riverside Dr., Unit 78, New York, NY, 10032, USA.
Michelle ConnorDepartment of Neurosurgery, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Jamie PiersonDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Lauren C ShuffreyDepartment of Psychiatry, New York State Psychiatric Institute, Columbia University, 1051 Riverside Dr., Unit 78, New York, NY, 10032, USA.
Randy D BlakelyBrain Institute and Department of Biomedical Science, Florida Atlantic University, Jupiter, FL, 33458, USA.
Susanne E AhmariDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Jeremy Veenstra-VanderWeeleDepartment of Psychiatry, New York State Psychiatric Institute, Columbia University, 1051 Riverside Dr., Unit 78, New York, NY, 10032, USA. jeremy.veenstra@nyspi.columbia.edu.ORCID http://orcid.org/0000-0002-6349-1076
New York Psychoanalytic Society and Institute · USUniversity of Pittsburgh · USVanderbilt University · USFlorida Atlantic University · US

Funding

Translational Research Training in Child PsychiatryT32MH016434 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Cristiane S. Duarte, Kate Dimond Fitzgerald · 1985 to 2026
$10.9M
Investigation of EAAT3 in OCD PathophysiologyR01MH114296 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI AHMARI, SUSANNE ELIZABETH, VEENSTRA-VANDERWEELE, JEREMY · 2017 to 2021
$2.7M
Neurobiological Signatures of Social Dysfunction and Repetitive BehaviorR01MH094604 · NIMH · VANDERBILT UNIVERSITY · PI VEENSTRA-VANDERWEELE, JEREMY · 2011 to 2015
$2.0M
Murine Genetic Models of AutismK08MH081066 · NIMH · VANDERBILT UNIVERSITY · PI VEENSTRA-VANDERWEELE, JEREMY · 2007 to 2011
$832k
NIH HHS MH081066NIH HHS MH094604NIH HHS T32MH016434NIMH NIH HHS K08 MH081066NIMH NIH HHS R01 MH094604NIMH NIH HHS R01 MH114296NIMH NIH HHS T32 MH016434
6 · The paper itself

Abstract

rationaleElevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT

objectivesWe examined the impact of the SERT Ala56 mutation, which leads to enhanced SERT function, on 5-HT

methodsSpecific binding to 5-HT

resultsWhile enhanced SERT function increased 5-HT

conclusionsWhile reducing 5-HT

Indexed as

Amino Acid SubstitutionAnimalsBehavior, AnimalFrontal LobeGene Expression RegulationGenotypeHyperkinesisIndolesMaleMiceMutationPrepulse InhibitionProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT1BSensory GatingSerotonin 5-HT1 Receptor Agonists5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indoleIndolesProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AgonistsSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouse5-HT1BASDAutism spectrum disorderObsessive-compulsive disorderOCDOrbitofrontal cortexPrepulse inhibition of startleRU24969Sensorimotor gatingSerotonin

Identifiers

PMID33511450
PMCPMC8728944
OpenAlexW3124780743

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.