ArticleApplied microbiology and biotechnology2021
The effect of different combinations of antibiotic cocktails on mice and selection of animal models for further microbiota research.
Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 44 citations in OpenAlex.
- Antibiotics administration during weaning ameliorates intestinal mucosal inflammation in adult mice and their offspring.Frontiers in immunology · 2026Article
- The hidden cost of antibiotics: microbial dysbiosis-induced SCFA imbalance and its underlying mechanisms.Frontiers in immunology · 2026Review
- Protective Effects of Ginseng Soluble Dietary Fiber and Its Fecal Microbiota Extract on Antibiotic-Induced Gut Dysbiosis Obese Mice.Journal of microbiology and biotechnology · 2025Article
- Modulation of the gut microbiota and the microbial-produced gut metabolites by diclofenac exposure and selenium supplementation.Environmental science and pollution research international · 2025Article
- Cefazolin shifts the kidney microbiota to promote a lithogenic environment.Nature communications · 2024Article
- Antibiotic Cocktail Effects on Intestinal Microbial Community, Barrier Function, and Immune Function in Early Broiler Chickens.Antibiotics (Basel, Switzerland) · 2024Article
- Pretreatment with an antibiotics cocktail enhances the protective effect of probiotics by regulating SCFA metabolism and Th1/Th2/Th17 cell immune responses.BMC microbiology · 2024Article
- Alteration of gut microbiome and metabolome byiScience · 2023Article
- Can antibiotics for enteritis or for urinary tract infection disrupt the urinary microbiota in rats?Frontiers in cellular and infection microbiology · 2023Article
- Depletion of Gut Microbiota Inhibits Hepatic Lipid Accumulation in High-Fat Diet-Fed Mice.International journal of molecular sciences · 2022Article
- Ocular microbiota promotes pathological angiogenesis and inflammation in sterile injury-driven corneal neovascularization.Mucosal immunology · 2022Article
- Non-absorbable antibiotic treatment inhibits colorectal cancer liver metastasis by modulating deoxycholic acid metabolism by intestinal microbes.Journal of Cancer · 2022Article
- Evaluation of an Antibiotic Cocktail for Fecal Microbiota Transplantation in Mouse.Frontiers in nutrition · 2022Article
- Uncovering the Mechanism of the Xingnaojing Injection against Ischemic Stroke Using a Combined Network Pharmacology Approach and Gut Microbiota Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Selection strategy of dextran sulfate sodium-induced acute or chronic colitis mouse models based on gut microbial profile.BMC microbiology · 2021Article
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Authors and funding
12 authors at 1 institution in 1 country.
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Abstract
The gut microbiota is closely related to host health and disease. However, there are no suitable animal models available at present for exploring its functions. We analyzed the effect of 3 different antibiotic cocktails (ABx) via two administration routes on the composition of murine gut microbiota, as well as on the general physiological and metabolic indices. High-throughput 16S rRNA sequencing showed that ABx treatment altered the gut microbiota community structure, and also caused low-degree inflammation in the colon. In addition, ad libitum administration of antibiotics depleted the gut microbiota more effectively compared to direct oral gavage, especially with 3ABx. The ABx treatment also had a significant impact on renal and liver functions, as indicated by the altered serum levels of creatinine, urea, total triglycerides, and total cholesterol. Finally, Spearman's correlation analysis showed that the predominant bacterial genera resulting from ABx intervention, including Lactobacillus, Roseburia, and Candidatus-Saccharimonas, were negatively correlated with renal function indices. Taken together, different antibiotic combinations and interventions deplete the gut microbiota and induce physiological changes in the host. Our findings provide the basis for developing an adaptive animal model for studying gut microbiota. KEY POINTS: • Ad libitum administration of 3ABx can effectively deplete intestinal microbiota. • ABx treatment may have slight effect on renal and liver function. • The levels of urea and creatinine correlated with the growth of Roseburia.
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