Evidence map›Paper›PMID 33511368›Full record

ArticlePatterns (New York, N.Y.)2021

SIMON: Open-Source Knowledge Discovery Platform.

Adriana Tomic, Ivan Tomic, Levi Waldron, Ludwig Geistlinger, Max Kuhn, Rachel L Spreng, Lindsay C Dahora, Kelly E Seaton, Georgia Tomaras, Jennifer Hill and 8 more

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Adriana TomicOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Ivan TomicDeep Medicine, Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Levi WaldronGraduate School of Public Health and Health Policy, City University of New York, New York, NY, USA.
Ludwig GeistlingerGraduate School of Public Health and Health Policy, City University of New York, New York, NY, USA.
Max KuhnRStudio, PBC, Boston, MA, USA.
Rachel L SprengDuke Human Vaccine Institute, Duke University, Durham, NC, USA.
Lindsay C DahoraDuke Human Vaccine Institute, Duke University, Durham, NC, USA.
Kelly E SeatonDuke Human Vaccine Institute, Duke University, Durham, NC, USA.
Georgia TomarasDuke Human Vaccine Institute, Duke University, Durham, NC, USA.
Jennifer HillOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Niharika A DuggalMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham Research Labs, Birmingham, UK.
Ross D PollockCentre for Human and Applied Physiological Sciences, King's College London, UK.
Norman R LazarusCentre for Human and Applied Physiological Sciences, King's College London, UK.
Stephen D R HarridgeCentre for Human and Applied Physiological Sciences, King's College London, UK.
Janet M LordMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham Research Labs, Birmingham, UK.
Purvesh KhatriInstitute of Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Mark M DavisInstitute of Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Cancer Genomics:Integrative and Scalable Solutions in R / BioconductorU24CA180996 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MORGAN, MARTIN T, WALDRON, LEVI · 2014 to 2023
$6.9M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
NCI NIH HHS U24 CA180996NIAID NIH HHS T32 AI052077NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

Data analysis and knowledge discovery has become more and more important in biology and medicine with the increasing complexity of biological datasets, but the necessarily sophisticated programming skills and in-depth understanding of algorithms needed pose barriers to most biologists and clinicians to perform such research. We have developed a modular open-source software, SIMON, to facilitate the application of 180+ state-of-the-art machine-learning algorithms to high-dimensional biomedical data. With an easy-to-use graphical user interface, standardized pipelines, and automated approach for machine learning and other statistical analysis methods, SIMON helps to identify optimal algorithms and provides a resource that empowers non-technical and technical researchers to identify crucial patterns in biomedical data.

Indexed as

artificial intelligenceautoMLbioinformaticscomputational biologydata miningdata sciencemachine learningsoftwaresystems biology

Identifiers

PMID33511368
PMCPMC7815964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.