Trial reportPain reports
Design and conduct of confirmatory chronic pain clinical trials.
Trial report in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Addressing chronic pain with Focused Acceptance and Commitment Therapy in integrated primary care: findings from a mixed methods pilot randomized controlled trial.BMC primary care · 2022Trial
- Trial
- The ACTTION Guide to Clinical Trials of Pain Treatments, part II: mitigating bias, maximizing value.Pain reportsTrial
- Improving Inclusion of Ethnically Diverse and Socioeconomically Disadvantaged Populations in Pain Research: A Comprehensive Review and Evidence-Based Recommendations.International journal of environmental research and public health · 2026Review
- Model-Informed Drug Development (MIDD) for Analgesics: Review of Applications, Regulatory Integration, and Emerging Directions.Journal of pain research · 2026Review
- An innovative phase 2 chronic pain master protocol design to assess novel mechanisms in multiple pain types.Pain reports · 2024Article
- Measurement of acute postoperative pain intensity in orthopedic trials: a qualitative concept elicitation study.Acta orthopaedica · 2024Article
- Covariate Adjustment in Chronic Pain Trials: An Oft-Missed Opportunity.The journal of pain · 2023Review
- Possible Strategies to Mitigate Placebo or Vehicle Response in Dry Eye Disease Trials: A Narrative Review.Ophthalmology and therapy · 2023Review
- Are psychedelic medicines the reset for chronic pain? Preliminary findings and research needs.Neuropharmacology · 2023Review
- Circulating Polyunsaturated Fatty Acids and Pain Intensity in Five Chronic Pain Conditions.The journal of pain · 2023Article
- Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials.Psychopharmacology · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this article is to provide readers with a basis for understanding the emerging science of clinical trials and to provide a set of practical, evidence-based suggestions for designing and executing confirmatory clinical trials in a manner that minimizes measurement error. The most important step in creating a mindset of quality clinical research is to abandon the antiquated concept that clinical trials are a method for capturing data from clinical practice and shifting to a concept of the clinical trial as a measurement system, consisting of an interconnected set of processes, each of which must be in calibration for the trial to generate an accurate and reliable estimate of the efficacy (and safety) of a given treatment. The status quo of inaccurate, unreliable, and protracted clinical trials is unacceptable and unsustainable. This article gathers aspects of study design and conduct under a single broad umbrella of techniques available to improve the accuracy and reliability of confirmatory clinical trials across traditional domain boundaries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.