Evidence map›Paper›PMID 33511246›Full record

ArticleMolecular therapy. Methods & clinical development2021

Spatiotemporal

Jacinta Jacob, Suchita Nadkarni, Alessia Volpe, Qi Peng, Sim L Tung, Rosalind F Hannen, Yasmin R Mohseni, Cristiano Scotta, Federica M Marelli-Berg, Robert I Lechler and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. CAR-mediated release of IL-10 increases the function of regulatory T cells: Relevance for future clinical application.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Gene editing enables non-invasiveMolecular therapy. Methods & clinical development · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jacinta JacobMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, Guy's Hospital, London SE1 9RT, UK.
Suchita NadkarniCentre for Cell Biology & Cutaneous Research, The Blizard Institute, Bart's and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Alessia VolpeImaging Therapies and Cancer Group, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Qi PengMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, Guy's Hospital, London SE1 9RT, UK.
Sim L TungMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, Guy's Hospital, London SE1 9RT, UK.
Rosalind F HannenCentre for Cell Biology & Cutaneous Research, The Blizard Institute, Bart's and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Yasmin R MohseniMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, Guy's Hospital, London SE1 9RT, UK.
Cristiano ScottaMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, Guy's Hospital, London SE1 9RT, UK.
Federica M Marelli-BergWilliam Harvey Research Institute, Bart's and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK.
Robert I LechlerMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, Guy's Hospital, London SE1 9RT, UK.
Lesley A SmythMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, Guy's Hospital, London SE1 9RT, UK.
Gilbert O FruhwirthImaging Therapies and Cancer Group, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Giovanna LombardiMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King's College London, Guy's Hospital, London SE1 9RT, UK.
Guy's Hospital · GBQueen Mary University of London · GBKing's College London · GB

Funding

British Heart Foundation CH/15/2/32064British Heart Foundation RG/13/12/30395British Heart Foundation RG/14/2/30616British Heart Foundation RG/20/8/34995Cancer Research UK 21153Medical Research Council MR/K025538/1
6 · The paper itself

Abstract

Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs has been shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clinical trials. Despite these successes, the

Indexed as

adoptive cell transfercell trackinghuman sodium iodide symporterinnate immune cellslentivirusmulti-modal imagingregulatory T cell therapyreporter geneSPECT/CT imagingtransplantation

Identifiers

PMID33511246
PMCPMC7811063
OpenAlexW3112501063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.