ArticleOpen forum infectious diseases2021
Occurrence of 4 Dengue Virus Serotypes and Chikungunya Virus in Kilombero Valley, Tanzania, During the Dengue Outbreak in 2018.
Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Viral and host determinants of arboviral disease severity in African populations: A systematic review with meta-analysis.PLoS neglected tropical diseases · 2026Pooled it
- Epidemiology, seroprevalence, and circulation of Chikungunya virus in Southern Africa (SADC region): A systematic review.PLoS neglected tropical diseases · 2026Pooled it
- Dengue Virus Infection and Associated Risk Factors in Africa: A Systematic Review and Meta-Analysis.Viruses · 2021Pooled it
- Insecticide susceptibility and knockdown resistance (Kdr) mutations (F1534C and V1016I) in Aedes aegypti populations from Dar es Salaam, Tanzania.Parasites & vectors · 2026Article
- Study of patients with acute undifferentiated fever identifies dengue as a growing threat to public health in Mali.PLoS neglected tropical diseases · 2026Article
- Article
- Detection of pathogens associated with acute febrile illness in children under five years of age in rural Tanzania.Scientific reports · 2025Article
- Arbovirus Epidemics as Global Health Imperative, Africa, 2023.Emerging infectious diseases · 2025Article
- Risk of Aedes-borne diseases in and around the Tanzanian seaport of Tanga despite community members being more concerned about malaria.Parasites & vectors · 2024Article
- Dengue virus transmission during non-outbreak period in Dar Es Salaam, Tanzania: a cross-sectional survey.BMC infectious diseases · 2024Article
- Molecular surveillance for dengue serotypes among the population living in Moyen-Ogooué province, Gabon; evidence of the presence of dengue serotype 1.Virology journal · 2024Article
- Exploratory analysis of the knowledge, attitudes and perceptions of healthcare workers about arboviruses in the context of surveillance in the Republic of Guinea.PLoS neglected tropical diseases · 2023Article
- Health professionals' knowledge on dengue and health facility preparedness for case detection: A cross-sectional study in Dar es Salaam, Tanzania.PLoS neglected tropical diseases · 2023Article
- A protocol for evaluating the entomological impact of larval source reduction on mosquito vectors at hotel compounds in Zanzibar.PloS one · 2023Article
- Uncovering the Burden of Dengue in Africa: Considerations on Magnitude, Misdiagnosis, and Ancestry.Viruses · 2022Review
- Aedes aegypti abundance, larval indices and risk for dengue virus transmission in Kinondoni district, Tanzania.Tropical medicine and health · 2022Article
- March 2019 dengue fever outbreak at the Kenyan south coast involving dengue virus serotype 3, genotypes III and V.PLOS global public health · 2022Article
- Risk factors for occurrence and abundance of Aedes aegypti and Aedes bromeliae at hotel compounds in Zanzibar.Parasites & vectors · 2021Article
- Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.PLoS neglected tropical diseases · 2021Article
- Seroprevalence of Dengue and Chikungunya antibodies among blood donors in Dar es Salaam and Zanzibar, Tanzania: a cross-sectional study.BMC infectious diseases · 2021Article
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Abstract
backgroundDengue and Chikungunya viruses can cause large-scale epidemics, with attack rates of up to 80%. In Tanzania, there have been repeated outbreaks of dengue fever, the most recent in 2018 and 2019, mostly affecting the coastal areas. Despite the importance of these viruses, there is limited knowledge on the epidemiology of dengue (DENV) and Chikungunya (CHIKV) in Tanzania. This study was conducted to investigate the prevalence of DENV and CHIKV in Kilombero Valley, Tanzania.
methodsA cross-sectional study was conducted at Kibaoni Health Center in Kilombero Valley, Southeastern Tanzania, in the rainy and dry seasons of 2018. Febrile patients of any age and gender were enrolled from the outpatient department. Blood samples were taken and screened for DENV and CHIKV viral RNA by real-time reverse transcription polymerase chain reaction assays.
resultsOverall, 294 patients were recruited. Most were females (65%), and one-third of patients were aged 14-25 years. DENV and CHIKV were detected in 29 (9.9%) and 3 (1.0%) patients, respectively. DENV was detected across all age groups during both the dry and rainy seasons. Although all 4 DENV serotypes were detected, serotypes 1 and 3 dominated and were present in 14 patients (42.4%) each. Additionally, the study showed DENV-1 and DENV-3 co-infections.
conclusionsThis study reveals the co-circulation of all 4 DENV serotypes and CHIKV in Kilombero. Importantly, we report the first occurrence of DENV-4 in Tanzania. Unlike previous DENV outbreaks caused by DENV-2, the 2018 outbreak was dominated by DENV-1 and DENV-3. The occurrence of all serotypes suggests the possibility of severe clinical outcomes in future DENV epidemics in Tanzania.
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