Evidence map›Paper›PMID 33511216›Full record

ArticleBioMed research international2021

Associations between Inflammatory Cytokine Gene Polymorphisms and Susceptibilities to Intracranial Aneurysm in Chinese Population.

Lu Xu, Liming Hu, Chongyu Hu, Junyu Liu, Bingyang Li, Xin Liao, Jilin Zhou, Songlin Liu, Yifeng Li, Dun Yuan and 2 more

Open access · hybridAbstract read

In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed, 2 pooled it

0.7field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-6 -174G>C and -572G>C (Part II).Acta bio-medica : Atenei Parmensis · 2022
Pooled it
Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-1β -511C>T (Part I).Acta bio-medica : Atenei Parmensis · 2022
Pooled it
Updated Trans-Ethnic Meta-Analysis of Associations between Inflammation-Related Genes and Intracranial Aneurysm.Journal of Korean Neurosurgical Society · 2023
Article
Understanding the genetics of intracranial aneurysms: A primer.Clinical neurology and neurosurgery · 2022
Review
Smoking, Hypertension, and GG Genotype of the IL-6 rs1800796 Polymorphism are Independent Risk Factors for Abdominal Aortic Aneurysm in Han Population.Pharmacogenomics and personalized medicine · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Lu XuDepartment of Neurosurgery, XiangYa Hospital, Central South University, Changsha, China.

Liming HuDepartment of Epidemiology and Health Statistics, XiangYa School of Public Health, Central South University, Changsha, China.ORCID https://orcid.org/0000-0002-0166-8585

Chongyu HuDepartment of Neurology, Hunan People's Hospital, Changsha, China.

Junyu LiuDepartment of Neurosurgery, XiangYa Hospital, Central South University, Changsha, China.

Bingyang LiDepartment of Epidemiology and Health Statistics, XiangYa School of Public Health, Central South University, Changsha, China.ORCID https://orcid.org/0000-0003-0138-773X

Xin LiaoThe People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.ORCID https://orcid.org/0000-0002-9640-8638

Jilin ZhouDepartment of Neurosurgery, XiangYa Hospital, Central South University, Changsha, China.

Songlin LiuDepartment of Neurosurgery, XiangYa Hospital, Central South University, Changsha, China.

Yifeng LiDepartment of Neurosurgery, XiangYa Hospital, Central South University, Changsha, China.

Dun YuanDepartment of Neurosurgery, XiangYa Hospital, Central South University, Changsha, China.

Weixi JiangDepartment of Neurosurgery, XiangYa Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0000-0003-1570-0854

Junxia YanDepartment of Epidemiology and Health Statistics, XiangYa School of Public Health, Central South University, Changsha, China.ORCID https://orcid.org/0000-0001-6067-1613

Central South University · CNHunan Provincial People's Hospital · CNThe People's Hospital of Guangxi Zhuang Autonomous Region · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracranial aneurysm (IA) is a complex disease caused by genetic and environmental factors. Evidence indicates that inflammation plays an important role in IA occurrence. We aimed to explore the associations between inflammatory cytokine gene polymorphisms and IA in a Chinese population. This study enrolled 768 participants of Han ethnicity, including 384 patients with IA and 384 healthy individuals. Sixteen single nucleotide polymorphisms (SNPs) of

Indexed as

Polymorphism, Single NucleotideAgedAsian PeopleCase-Control StudiesCytokinesFemaleGenetic Predisposition to DiseaseHumansInflammationInterleukin-12 Subunit p40Interleukin-1alphaInterleukin-6Intracranial AneurysmLinkage DisequilibriumMaleMiddle AgedCytokinesIL12B protein, humanIL1A protein, humanIL6 protein, humanInterleukin-12 Subunit p40Interleukin-1alphaInterleukin-6TNF protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID33511216

DOI10.1155/2021/8865601

PMCPMC7826207

OpenAlexW3124154288

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.