ArticleBioMed research international2021
Proteomic Profiling Reveals the Molecular Changes of Insomnia Patients.
Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Identification of therapeutic targets for insomnia through genetic and plasma proteomic approaches.Medicine · 2025Pooled it
- Plasma proteomics of sleep traits reveals systemic immune-metabolic pathways and genetically prioritized proteins.Molecular psychiatry · 2026Article
- Hazardous alcohol use and cardiometabolic risk among firefighters.Alcohol, clinical & experimental research · 2025Article
- Human serum proteomics reveals a molecular signature after one night of sleep deprivation.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Proteomics Reveals Molecular Changes in Insomnia Patients with More Dreams.Computational and mathematical methods in medicine · 2022Article
- B serum proteome profiles revealed dysregulated proteins and mechanisms associated with insomnia patients: A preliminary study.Frontiers in integrative neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsomnia is an economic burden and public health problem. This study is aimed at exploring potential biological pathways and protein networks for insomnia characterized by wakefulness after sleep.
methodProteomics analysis was performed in the insomnia group with wakefulness and the control group. The differentially expressed proteins (DEPs) were enriched; then, hub proteins were identified by protein-protein interaction (PPI) network and verified by parallel reaction monitoring (PRM).
resultsCompared with the control group, the sleep time and efficiency of insomnia patients were decreased, and awakening time and numbers after sleep onset were significantly increased (
conclusionWe identified the hub proteins and molecular mechanisms of insomnia patients characterized by wakefulness after sleep. It provided potential molecular targets for the clinical diagnosis and treatment of these patients and indicated that the immune and metabolic systems may be closely related to insomnia characterized by wakefulness after sleep.
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Registered trials
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