ArticleWorld journal of clinical cases2021
Primary lung cancer with radioiodine avidity: A thyroid cancer cohort study.
Article in World journal of clinical cases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- The extra-thyroidal distribution of sodium iodide symporter.Frontiers in endocrinology · 2025Review
- Review
- Effect of a prior thyroid cancer on the survival of lung cancer patients: a retrospective study based on SEER database.Endocrine · 2024Article
- Risk Factors and Prognosis for Metastatic Follicular Thyroid Cancer.Frontiers in endocrinology · 2022Article
- Outcomes of Patients With Metastatic Differentiated Thyroid Cancer After Excellent Response to Treatment.Frontiers in endocrinology · 2022Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundA proportion of lung cancers show sodium/iodide symporter (NIS) expression. Lung cancers with NIS expression may uptake radioiodine (RAI) and show RAI-avid lesions on RAI scan for differentiated thyroid cancer (DTC) surveillance.
aimTo investigate the possibility of RAI uptake by lung cancer in a cohort with thyroid cancer.
methodsRAI-avid lung cancers were analyzed using a prospectively maintained database of patients with thyroid cancer who were registered at a medical center between December 1, 1976 and May 28, 2018. NIS expression in lung cancer was assessed using immunohistochemical staining.
resultsOf the 5000 patients with thyroid cancer from the studied dataset, 4602 had DTC. During follow-up, 33 patients developed primary lung cancer. Of these patients, nine received an iodine-131 (
conclusionA proportion of lung cancer demonstrates NIS expression and is RAI-avid. Clinicians should be aware of this possibility in the interpretation of RAI scintigraphy.
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