Evidence map›Paper›PMID 33511062›Full record

ArticleJournal of traditional and complementary medicine2021

Nephroprotective effect of

Omar Sekiou, Mahieddine Boumendjel, Faiza Taibi, Lazhari Tichati, Amel Boumendjel, Mahfoud Messarah

Open access · diamondAbstract read
In one paragraph

Article in Journal of traditional and complementary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  4. Article
  5. Spray-Drying Microencapsulation ofMolecules (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Traditional Knowledge of Medicinal Plants Used in the Northeastern Part of Morocco.Evidence-based complementary and alternative medicine : eCAM · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Omar SekiouLaboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, University of Badji Mokhtar, BP 12 Sidi Amar, Annaba, Algeria.
Mahieddine BoumendjelLaboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, University of Badji Mokhtar, BP 12 Sidi Amar, Annaba, Algeria.
Faiza TaibiLaboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, University of Badji Mokhtar, BP 12 Sidi Amar, Annaba, Algeria.
Lazhari TichatiLaboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, University of Badji Mokhtar, BP 12 Sidi Amar, Annaba, Algeria.
Amel BoumendjelLaboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, University of Badji Mokhtar, BP 12 Sidi Amar, Annaba, Algeria.
Mahfoud MessarahLaboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, University of Badji Mokhtar, BP 12 Sidi Amar, Annaba, Algeria.
Badji Mokhtar University · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimIn the present study, we investigate the phytochemical composition and the nephroprotective effects as well as the antioxidant properties of EXPERIMENTAL PROCEDURE: Wistar rats were divided into four groups of seven rats each: Group I: Normal control (NC) received saline solution at 9‰ given by intraperitoneal way; Group II: Diabetic control (DC) received alloxan (150 mg/kg b.w) intraperitoneally; Group III: Normal control (NC + AHA) received saline solution at 9‰ and treated orally by AHA aqueous extract (400 mg/kg/b.w); Group IV: Diabetic control (DC + AHA) received alloxan solution (150 mg/kg b.w) intraperitoneally and treated by aqueous extract of AHA (400 mg/kg/b.w/day) orally after one week of alloxan administration. After 30 days, blood and tissue samples were collected for biochemical and histopathological analysis, respectively. Glomerular damage markers, including creatinine, serum urea, urine creatinine and urine urea levels were estimated. Creatinine clearance was also assessed. Oxidative stress parameters were assessed in the kidney homogenate. RESULTS AND

conclusionAlloxan-exposure resulted in significant increase in blood glucose and serum level of glomerular damage markers. The antioxidant enzyme activities were significantly downregulated associated with an increase in malondialdehyde (MDA) level over the baseline values.

Indexed as

AHA, Artemisia herba-albaAlCl3, Aluminum trichlorideArtemisia herba albaCAT, catalaseDC, Diabetic controlDiabetesDPPH, 1,1-diphenyl-2-picrylhydrazylDTNB, 5,5-dithiobis (2-nitrobenzoic acid)Free radicalsGPx, glutathione peroxidaseGSH, reduced glutathioneGST, glutathione-S-transferaseH2O2, hydrogen peroxideMDA, malondialdehydeNBT, Nitro-blue tetrazoliumNephroprotectionOxidative stressRFC, Folin-CiocalteuROS, reactive oxygen speciesSOD, superoxide dismutaseSTZ, streptozotocinTBA, thiobarbituric acidTCA, trichloroacetic acid

Identifiers

PMID33511062
PMCPMC7817709
OpenAlexW2999675585

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.