Effects of onopordia, a novel isolated compound from

Malihe Hassanzadeh, Niusha Sharifi, Shabnam Mahernia, Nastaran Rahimi, Ahmad Reza Dehpour, Massoud Amanlou

Open access · diamondAbstract read

In one paragraph

Article in Journal of traditional and complementary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.5field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Malihe HassanzadehDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Niusha SharifiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Shabnam MaherniaThe Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

Nastaran RahimiExperimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Ahmad Reza DehpourExperimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Massoud AmanlouDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Tehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is identified as a brain disorder and characterized by unpredictable disruption of normal brain function. Due to adverse side effect associated with antiepileptic drugs and also resistance profile, improvement of antiepileptic medications with more beneficial anticonvulsant activity is essential. Natural products have demonstrated their therapeutic properties such as anxiolytic, antidepressant and anticonvulsant activities and a source for identification of novel lead compounds. Therefore, the purpose of this study was to evaluate the effects of

Indexed as

7-NI, 7-nitroindazoleAG, Aminoguanidine hydrochlorideDMSO, dimethyl sulfoxideeNOS, endothelial NOSGABA, gamma-aminobutyric acidiNOS, inducible NOSip, intraperitoneallyiv, intravenouslyL-Arg, l-argininel-NAME, Nω-nitro-l-arginine methyl ester hydrochlorideMiceNitric oxideNitric oxide synthase inhibitorsN-Methyl-d-aspartic acid, NMDAnNOS, neuronal NOSNOS, nitric oxide synthaseOnopordon acanthiumPentylenetetrazolePTZ, pentylenetetrazoleSeizure

Identifiers

PMID33511058

DOI10.1016/j.jtcme.2019.11.005

PMCPMC7817707

OpenAlexW2989931790

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.