Evidence map›Paper›PMID 33510963›Full record

ArticleTranslational vision science & technology2021

A Cross-Sectional Study of Sub-Basal Corneal Nerve Reduction Following Neurotoxic Chemotherapy.

Jeremy Chung Bo Chiang, David Goldstein, Terry Trinh, Kimberley Au, David Mizrahi, Mark Muhlmann, Philip Crowe, Siobhan O'Neill, Katie Edwards, Susanna B Park and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Evaluation of Corneal Sensitivity: Tools We Have.Diagnostics (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jeremy Chung Bo ChiangSchool of Optometry & Vision Science, University of New South Wales, Sydney, Australia.
David GoldsteinPrince of Wales Clinical School, University of New South Wales, Sydney, Australia.
Terry TrinhPrince of Wales Clinical School, University of New South Wales, Sydney, Australia.
Kimberley AuPrince of Wales Clinical School, University of New South Wales, Sydney, Australia.
David MizrahiPrince of Wales Clinical School, University of New South Wales, Sydney, Australia.
Mark MuhlmannPrince of Wales Clinical School, University of New South Wales, Sydney, Australia.
Philip CrowePrince of Wales Clinical School, University of New South Wales, Sydney, Australia.
Siobhan O'NeillDepartment of Medical Oncology, Prince of Wales Hospital, Sydney, Australia.
Katie EdwardsInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Susanna B ParkBrain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Arun V KrishnanPrince of Wales Clinical School, University of New South Wales, Sydney, Australia.
Maria MarkoulliSchool of Optometry & Vision Science, University of New South Wales, Sydney, Australia.
UNSW Sydney · AUPrince of Wales Hospital · AUQueensland University of Technology · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Sub-basal corneal nerves have been shown to change during neurotoxic chemotherapy treatment. This cross-sectional study investigated corneal nerve morphology in patients who have completed neurotoxic chemotherapy well after treatment cessation and its association with peripheral nerve function. Methods: Central corneal nerve fiber length (CNFL) and inferior whorl length (IWL), average nerve fiber length (ANFL), corneal nerve fiber density (CNFD) and corneal nerve branch density (CNBD), and nerve fiber area (CNFA) were examined using in vivo corneal confocal microscopy in patients with cancer who had completed treatment with either paclitaxel or oxaliplatin between 3 and 24 months prior to assessment in comparison with 2 separate groups of healthy controls. Neurological assessments were conducted including clinician- and patient-reported outcomes, and neurological grading scales. Results: Both paclitaxel- ( Conclusions: There is evidence of corneal nerve loss in patients with cancer who have been treated with paclitaxel and oxaliplatin well after treatment cessation associated with worse upper limb function. Translational Relevance: Sub-basal corneal nerve reduction is evident even after cessation of neurotoxic treatment. In vivo corneal confocal microscopy may be useful in the monitoring of nerve function in patients receiving chemotherapy.

Indexed as

Diabetic NeuropathiesCorneaCross-Sectional StudiesHumansMicroscopy, ConfocalNerve Fiberschemotherapy-induced peripheral neuropathycorneal nervesinferior whorlin-vivo corneal confocal microscopyneurotoxic chemotherapy

Identifiers

PMID33510963
PMCPMC7804570
OpenAlexW3120632127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.