Evidence map›Paper›PMID 33510954›Full record

ArticleTranslational vision science & technology2021

Central Serous Chorioretinopathy Analyzed by Multimodal Imaging.

Liang Han, Jose Ronaldo Lima de Carvalho, Rait Parmann, Tongalp H Tezel, Stanley Chang, Tarun Sharma, Janet R Sparrow

Abstract read
In one paragraph

Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Primary versus Secondary Elevations in Fundus Autofluorescence.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liang HanDepartment of Ophthalmology, Columbia University, New York, New York, USA.
Jose Ronaldo Lima de CarvalhoDepartment of Ophthalmology, Columbia University, New York, New York, USA.
Rait ParmannDepartment of Ophthalmology, Columbia University, New York, New York, USA.
Tongalp H TezelDepartment of Ophthalmology, Columbia University, New York, New York, USA.
Stanley ChangDepartment of Ophthalmology, Columbia University, New York, New York, USA.
Tarun SharmaDepartment of Ophthalmology, Columbia University, New York, New York, USA.
Janet R SparrowDepartment of Ophthalmology, Columbia University, New York, New York, USA.

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
Quantitative Fundus Autofluorescence in Retinal DisordersR01EY024091 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPARROW, JANET RUTHE · 2014 to 2022
$3.4M
NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY024091
6 · The paper itself

Abstract

Purpose: We correlated quantitative fundus autofluorescence (qAF) with other fundus features in patients exhibiting central serous chorioretinopathy (CSC). Methods: Short wavelength fundus autofluorescence (SW-AF, 488 nm excitation) was measured by qAF. Using nonnormalized images qAF values were calculated within eight concentric segments (qAF Results: Thirty-six eyes of 20 patients (mean age 48.7± 8.5 years) diagnosed with CSC were studied. Thirteen patients had bilateral disease; four patients were female. In 22 eyes CSC was present in the macula; in one eye the lesion was in a peripapillary location, 10 involved both locations, and three were unaffected. Serous retinal detachment, retinal pigmented epithelial detachment (PED), outer retinal atrophy and subRPE hypertransmission were all features identifiable by SD-OCT. NIR-AF images were helpful in detecting foveal and parafoveal lesions. Sampling for retina-wide elevations in SW-AF intensity by measuring qAF Conclusions: Localized elevations in qAF reflect increased bisretinoid in association with CSC lesions. Translational Relevance: Foci of elevated qAF at some stages of CSC contribute to the natural history of the disease.

Indexed as

Central Serous ChorioretinopathyAdultFemaleFluorescein AngiographyFundus OculiHumansMiddle AgedMultimodal ImagingTomography, Optical Coherencecentral serous chorioretinopathyfundus autofluorescencenear infrared fundus autofluorescencephotoreceptorquantitative fundus autofluorescenceretinal pigment epitheliumshort-wavelength fundus autofluorescencespectral domain optical coherence tomography

Identifiers

PMID33510954
PMCPMC7804571

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.