Evidence map›Paper›PMID 33510951›Full record

ArticleTranslational vision science & technology2021

Predicting Age From Optical Coherence Tomography Scans With Deep Learning.

Leonardo S Shigueoka, Eduardo B Mariottoni, Atalie C Thompson, Alessandro A Jammal, Vital P Costa, Felipe A Medeiros

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  8. A Deep Learning Approach to Predict Chronological Age.Healthcare (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Leonardo S ShigueokaVision, Imaging and Performance Laboratory (VIP), Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC, USA.
Eduardo B MariottoniVision, Imaging and Performance Laboratory (VIP), Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC, USA.
Atalie C ThompsonVision, Imaging and Performance Laboratory (VIP), Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC, USA.
Alessandro A JammalVision, Imaging and Performance Laboratory (VIP), Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC, USA.
Vital P CostaGlaucoma Service, Department of Ophthalmology, University of Campinas, Campinas, São Paulo, Brazil.
Felipe A MedeirosVision, Imaging and Performance Laboratory (VIP), Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC, USA.
Duke University · USUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

The BCI (Brain Computer Interface) Glaucoma Study: Objective Home-Based Detection of Progressive Visual Function Loss in GlaucomaR01EY029885 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ASRANI, SANJAY, MEDEIROS, FELIPE · 2019 to 2022
$2.2M
Objective Quantification of Neural Damage for Screening, Diagnosis and Monitoring of Glaucoma with Fundus PhotographsR21EY031898 · NEI · DUKE UNIVERSITY · PI MEDEIROS, FELIPE · 2020 to 2021
$437k
NEI NIH HHS R01 EY029885NEI NIH HHS R21 EY031898
6 · The paper itself

Abstract

Purpose: To assess whether age can be predicted from deep learning analysis of peripapillary spectral-domain optical coherence tomography (SD-OCT) B-scans and to determine the importance of specific retinal areas on the predictions. Methods: Deep learning (DL) convolutional neural networks were developed to predict chronological age in healthy subjects using peripapillary SD-OCT B-scan images. Models were built using the whole B-scan, as well as using specific regions through image ablation. Cross-validation was used for training and testing the model. Mean absolute error (MAE) and correlations between predicted and observed age were used to evaluate model performance. Results: A total of 7271 images from 542 eyes of 278 healthy subjects were included. DL predictions of age using the whole B-scan were strongly correlated with chronological age (MAE = 5.82 years; Conclusions: A DL algorithm was able to accurately predict age from whole peripapillary SD-OCT B-scans. Translational Relevance: DL models applied to SD-OCT scans suggest that aging appears to affect several layers in the posterior eye segment.

Indexed as

Deep LearningTomography, Optical CoherenceAlgorithmsChild, PreschoolHumansNeural Networks, ComputerROC Curveagingartificial intelligencedeep learningoptical tomography coherenceposterior eye segment

Identifiers

PMID33510951
PMCPMC7804495
OpenAlexW3118468002

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.