Evidence map›Paper›PMID 33510930›Full record

ArticleJournal of analytical methods in chemistry2021

Quantitation of Apremilast in Beagle Dogs Plasma by UPLC-MS-MS and Its Application to Pharmacokinetic Studies.

Wei Xiong, Ling Wang, Haiyan Zhang, Xiaoqiu Tao, Xuehua Jiang, Zejuan Liu, Jiajia Zhao, Wenwen Xu

Open access · goldAbstract read
In one paragraph

Article in Journal of analytical methods in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wei XiongDepartment of Clinical Pharmacy, Pharmacy School of Sichuan University, Chengdu, Sichuan 610041, China.ORCID https://orcid.org/0000-0001-5103-0099
Ling WangDepartment of Clinical Pharmacy, Pharmacy School of Sichuan University, Chengdu, Sichuan 610041, China.ORCID https://orcid.org/0000-0003-3220-6065
Haiyan ZhangSichuan Tobacco Quality Supervision and Testing Station, Chengdu, China.ORCID https://orcid.org/0000-0001-9808-449X
Xiaoqiu TaoSichuan Tobacco Quality Supervision and Testing Station, Chengdu, China.ORCID https://orcid.org/0000-0003-2964-7206
Xuehua JiangDepartment of Clinical Pharmacy, Pharmacy School of Sichuan University, Chengdu, Sichuan 610041, China.ORCID https://orcid.org/0000-0001-8070-3117
Zejuan LiuDepartment of Clinical Pharmacy, Pharmacy School of Sichuan University, Chengdu, Sichuan 610041, China.
Jiajia ZhaoDepartment of Clinical Pharmacy, Pharmacy School of Sichuan University, Chengdu, Sichuan 610041, China.ORCID https://orcid.org/0000-0001-8899-6356
Wenwen XuDepartment of Clinical Pharmacy, Pharmacy School of Sichuan University, Chengdu, Sichuan 610041, China.ORCID https://orcid.org/0000-0002-2574-7608
Sichuan University · CNChina Tobacco · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method for the determination of apremilast in beagle dog plasma has been developed and successfully validated in the current study. Clopidogrel was employed as an internal standard (IS), and liquid-liquid extraction by tert-butylmethyl ether was used for sample preparation. Chromatographic separation was achieved on a UPLC BEH Shield RP18 column (50 mm × 2.1 mm, 1.7

Identifiers

PMID33510930
PMCPMC7826237
OpenAlexW3123124175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.