Evidence map›Paper›PMID 33510789›Full record

ArticleJournal of oncology2021

MicroRNA-Based Cancer Mortality Risk Scoring System and hTERT Expression in Early-Stage Oral Squamous Cell Carcinoma.

Angela J Yoon, Regina M Santella, Shuang Wang, David I Kutler, Richard D Carvajal, Elizabeth Philipone, Tian Wang, Scott M Peters, Claire R Stewart, Fatemeh Momen-Heravi and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Angela J YoonColumbia University Irving Medical Center, New York, NY, USA.ORCID https://orcid.org/0000-0002-0529-7195
Regina M SantellaColumbia University Mailman School of Public Health, New York, NY, USA.
Shuang WangColumbia University Mailman School of Public Health, New York, NY, USA.
David I KutlerWeill Cornell Medicine, New York, NY, USA.
Richard D CarvajalColumbia University Irving Medical Center, New York, NY, USA.
Elizabeth PhiliponeColumbia University Irving Medical Center, New York, NY, USA.
Tian WangColumbia University Mailman School of Public Health, New York, NY, USA.
Scott M PetersColumbia University Irving Medical Center, New York, NY, USA.
Claire R StewartWeill Cornell Medicine, New York, NY, USA.
Fatemeh Momen-HeraviColumbia University Irving Medical Center, New York, NY, USA.
Scott TroobColumbia University Irving Medical Center, New York, NY, USA.
Matt LevinCell IDx, San Diego, CA, USA.
Zohreh AkhavanAghdamCell IDx, San Diego, CA, USA.
Austin J ShackelfordColumbia University Irving Medical Center, New York, NY, USA.
Carleigh R CanterburyColumbia University Irving Medical Center, New York, NY, USA.
Masataka ShimonosonoColumbia University Irving Medical Center, New York, NY, USA.
Brenda Y HernandezHawaii Tumor Registry, University of Hawaii Cancer Center, Honolulu, HI, USA.
Bradley D McDowellHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
Hiroshi NakagawaColumbia University Irving Medical Center, New York, NY, USA.
Columbia University Irving Medical Center · USColumbia University · USCell IDx (United States) · USCornell University · USUniversity of Hawaiʻi at Mānoa · USUniversity of Iowa · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7M
Transformed Esophageal Epithelial Cells and the Tumor MicroenvironmentP01CA098101 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2003 to 2023
$31.7M
Aldh2 and mitochondrial homeostasis in esophageal pathobiologyR01AA026297 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Hiroshi Nakagawa · 2018 to 2026
$2.9M
Building a patient-centered cancer data mart in a rural stateR50CA243692 · NCI · UNIVERSITY OF IOWA · PI MCDOWELL, BRADLEY D · 2019 to 2023
$490k
NCI NIH HHS P01 CA098101NCI NIH HHS P30 CA013696NCI NIH HHS P30 CA086862NCI NIH HHS R50 CA243692NIAAA NIH HHS R01 AA026297NIDCR NIH HHS L30 DE029070NIEHS NIH HHS P30 ES009089
6 · The paper itself

Abstract

We have previously constructed a novel microRNA (miRNA)-based prognostic model and cancer-specific mortality risk score formula to predict survival outcome in oral squamous cell carcinoma (OSCC) patients who are already categorized into "early-stage" by the TNM staging system. A total of 836 early-stage OSCC patients were assigned the mortality risk scores. We evaluated the efficacy of various treatment regimens in terms of survival benefit compared to surgery only in patients stratified into high (risk score ≥0) versus low (risk score <0) mortality risk categories. For the high-risk group, surgery with neck dissection significantly improved the 5-year survival to 75% from 46% with surgery only (

Identifiers

PMID33510789
PMCPMC7822680
OpenAlexW3120917380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.