ArticleNature microbiology2021
Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses.
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Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- The Flavivirus NS3 Protein: Its Multifaceted Roles and Therapeutic Potential.Journal of medical virology · 2026Review
- Host protein cleavage by Dengue and Zika virus NS3 proteases: from substrate identification to potential biological consequences.Frontiers in cellular and infection microbiology · 2026Review
- Intracranial calcifications in congenital viral infections: mechanisms and cellular roles.Current opinion in virology · 2025Review
- Zika Virus: A Tale of Two Lineages.Pathogens (Basel, Switzerland) · 2025Review
- Neurovascular pericytes are susceptible to infection by JC polyomavirus.Journal of virology · 2025Article
- A decade later, what have we learned from the Zika epidemic in children with intrauterine exposure?Lancet (London, England) · 2025Review
- Zika virus-induced fetal demise is triggered by strain- and dose-specific RLR-driven activation of the interferon response in the decidua, placenta, and fetus inJournal of virology · 2025Article
- Article
- Early and Long-Term Adverse Outcomes of In Utero Zika Exposure.Pediatrics · 2025Article
- TRIMming down Flavivirus Infections.Viruses · 2024Review
- Mechanistic insights into bone remodelling dysregulation by human viral pathogens.Nature microbiology · 2024Review
- Mechanisms of Zika astrocyte infection and neuronal toxicity.NeuroImmune pharmacology and therapeutics · 2023Article
- RIG-I and MDA5 are modulated by bone morphogenetic protein (BMP6) and are essential for restricting Zika virus infection in human Sertoli cells.Frontiers in microbiology · 2022Article
- Let's Get Physical: Flavivirus-Host Protein-Protein Interactions in Replication and Pathogenesis.Frontiers in microbiology · 2022Review
- Studying the Inflammatory Responses to Amyloid Beta Oligomers in Brain-Specific Pericyte and Endothelial Co-culture from Human Stem Cells.Frontiers in chemical engineering · 2022Article
- SARS-CoV-2 (COVID-19) as a possible risk factor for neurodevelopmental disorders.Frontiers in neuroscience · 2022Review
- The Interplay Between Brain Vascular Calcification and Microglia.Frontiers in aging neuroscience · 2022Review
- Zika Virus and Neuropathogenesis: The Unanswered Question of Which Strain Is More Prone to Causing Microcephaly and Other Neurological Defects.Frontiers in cellular neuroscience · 2021Review
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Authors and funding
14 authors at 6 institutions in 2 countries.
Weiqiang ChenDepartment of Cancer Biology and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Suan-Sin FooDepartment of Cancer Biology and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Eunjin HongKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Christine WuKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Wai-Suet LeeKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Shin-Ae LeeDepartment of Cancer Biology and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Denis EvseenkoKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Maria Elisabeth Lopes MoreiraClinical Research Unit, Fernandes Figueira Institute-FioCruz, Flamengo, Rio De Janeiro, Brazil.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6551-1827
Genhong ChengDepartment of Microbiology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6713-2783
Karin Nielsen-SainesDivision of Pediatric Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1742-5211
Patrícia BrasilLaboratório de Pesquisa Clínica em Doenças Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, FioCruz, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-9555-7976
Elyzabeth Avvad-PortariDepartment of Pathology, Fernandes Figueira Institute-FioCruz, Rio De Janeiro, Brazil.
Jae U JungDepartment of Cancer Biology and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. jungj@ccf.org.ORCID http://orcid.org/0000-0003-4559-8774
Cleveland Clinic Lerner College of Medicine · USUniversity of Southern California · USFundação Oswaldo Cruz · BRUniversity of California, Los Angeles · USIcahn School of Medicine at Mount Sinai · USInstituto Evandro Chagas · BR
Funding
Project 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZHU, JUN · 2015 to 2021
$46.6MVirology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G · 1991 to 2018
$39.9MMolecular Basis of KSHV oncogenesisR35CA200422 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2016 to 2022
$6.1MViral Mediated Type I Interferon InductionR01AI069120 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHENG, GENHONG · 2006 to 2021
$6.0MKSHV Epigenetic RegulationR01DE023926 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2013 to 2024
$4.2MSFTSV nonstructural protein NSs-mediated immunopathogenesisR01AI140705 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2018 to 2022
$4.2MGenetic evolution, pathogenesis and immune responses in mother to child transmission of ZIKVR01AI140718 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHENG, GENHONG, JUNG, JAE U · 2018 to 2022
$3.8MMechanisms of Biodefense By Toll-Like ReceptorsR01AI056154 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHENG, GENHONG · 2004 to 2014
$3.7MGP130/STAT3 signalling in articular cartilage development and regenerationR01AR071734 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EVSEENKO, DENIS, LYONS, KAREN M. · 2018 to 2022
$3.0MTickborne SFTS Virus Vaccine DevelopmentR01AI152190 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI JUNG, JAE U · 2020 to 2024
$2.9MStructural analysis and therapeutic nanobody development of KSHV G-protein coupled receptorR01CA251275 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI JUNG, JAE U · 2020 to 2024
$2.5MKSHVmediated regulation of proline metabolismR01DE028521 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2019 to 2023
$2.4MNCI NIH HHS R01 CA251275NCI NIH HHS R35 CA200422NIAID NIH HHS P30 AI028697NIAID NIH HHS R01 AI056154NIAID NIH HHS R01 AI069120NIAID NIH HHS R01 AI078389NIAID NIH HHS R01 AI116585NIAID NIH HHS R01 AI140705NIAID NIH HHS R01 AI140718NIAID NIH HHS R01 AI152190NIAID NIH HHS R21 AI129486NIAID NIH HHS R21 AI129534NIAID NIH HHS R56 AI078389NIAID NIH HHS U19 AI118610NIAMS NIH HHS R01 AR071734NIA NIH HHS R01 AG058624NIDCR NIH HHS K99 DE028573NIDCR NIH HHS R00 DE028573NIDCR NIH HHS R01 DE023926NIDCR NIH HHS R01 DE028521NIDCR NIH HHS R21 DE027888
Abstract
The most frequent fetal birth defect associated with prenatal Zika virus (ZIKV) infection is brain calcification, which in turn may potentially affect neurological development in infants. Understanding the mechanism could inform the development of potential therapies against prenatal ZIKV brain calcification. In perivascular cells, bone morphogenetic protein (BMP) is an osteogenic factor that undergoes maturation to activate osteogenesis and calcification. Here, we show that ZIKV infection of cultivated primary human brain pericytes triggers BMP2 maturation, leading to osteogenic gene expression and calcification. We observed extensive calcification near ZIKV
Indexed as
AnimalsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsBrainCalcinosisCalciumCells, CulturedDEAD-box RNA HelicasesFetusHumansInfectious Disease Transmission, VerticalMiceMice, TransgenicNucleoside-TriphosphataseOsteogenesisPericytesBMP2 protein, humanBone Morphogenetic Protein 2Bone Morphogenetic ProteinsCalciumDEAD-box RNA HelicasesNS3 protein, Zika virusNucleoside-TriphosphataseSerine EndopeptidasesSTAT2 protein, humanSTAT2 Transcription FactorViral ProteasesViral Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.