ArticleBritish journal of cancer2021
Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study.
Article in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- A contextual genomic perspective on physical activity and its relationship to health, well being and illness.Nature genetics · 2025Pooled it
- Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.Nature genetics · 2022Pooled it
- A case-control study of dietary patterns and lifestyle factors affecting colorectal cancer in Hunan province, South China.Medicine · 2026Article
- Sedentary behaviour and cancer risk: a World Cancer Research Fund International Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.medRxiv : the preprint server for health sciences · 2026Article
- Cardiovascular health assessed by Life's Essential 8 score, genetic risk, colonoscopy status, and risk of colorectal cancer: an analysis of UK Biobank.BMJ open gastroenterology · 2026Article
- A prospective investigation of early-onset colorectal cancer risk factors-pooled analysis of three large-scale European cohorts.British journal of cancer · 2026Article
- Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study.JNCI cancer spectrum · 2025Observational
- Physical activity, air pollution, and incident long-term conditions: a prospective cohort study.BMC medicine · 2025Article
- Physical Exercise as a Therapeutic Approach in Gastrointestinal Diseases.Journal of clinical medicine · 2025Review
- Causal role of plasma liposome in diabetic retinopathy: mendelian randomization (MR) study.Diabetology & metabolic syndrome · 2025Article
- From London buses to activity trackers: A reflection of 70 years of physical activity research.Journal of sport and health science · 2024Article
- Mendelian randomisation analysis for intestinal disease: achievement and future.eGastroenterology · 2024Review
- Univariable and multivariable Mendelian randomization study identified the key role of gut microbiota in immunotherapeutic toxicity.European journal of medical research · 2024Article
- Healthy lifestyle and life expectancy free of major chronic diseases at age 40 in China.Nature human behaviour · 2023Article
- Exercise sustains the hallmarks of health.Journal of sport and health science · 2023Review
- Association between physical activity and cancer risk among Chinese adults: a 10-year prospective study.The international journal of behavioral nutrition and physical activity · 2022Article
- Acute aerobic exercise-conditioned serum reduces colon cancer cell proliferation in vitro through interleukin-6-induced regulation of DNA damage.International journal of cancer · 2022Article
- Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods.Environmental health perspectives · 2022Article
- The causal relationship between obesity and skin and soft tissue infections: A two-sample Mendelian randomization study.Frontiers in endocrinology · 2022Article
- The Association of Waist Circumference with the Prevalence and Survival of Digestive Tract Cancer in US Adults: A Population Study Based on Machine Learning Methods.Computational and mathematical methods in medicine · 2022Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundWe conducted a Mendelian randomisation (MR) study to investigate whether physical activity (PA) causes a reduction of colorectal cancer risk and to understand the contributions of effects mediated through changes in body fat.
methodsCommon genetic variants associated with self-reported moderate-to-vigorous PA (MVPA), acceleration vector magnitude PA (AMPA) and sedentary time were used as instrumental variables. To control for confounding effects of obesity, we included instrumental variables for body mass index (BMI), body fat percentage, waist circumference and arm, trunk and leg fat ratios. We analysed the effect of these instrumental variables in a colorectal cancer genome-wide association study comprising 31,197 cases and 61,770 controls of European ancestry by applying two-sample and multivariable MR study designs.
resultsWe found decreased colorectal cancer risk for genetically represented measures of MVPA and AMPA that were additional to effects mediated through genetic measures of obesity. Odds ratio and 95% confidence interval (CI) per standard deviation increase in MVPA and AMPA was 0.56 (0.31, 1.01) and 0.60 (0.41, 0.88), respectively. No association has been found between sedentary time and colorectal cancer risk. The proportion of effect mediated through BMI was 2% (95% CI: 0, 14) and 32% (95% CI: 12, 46) for MVPA and AMPA, respectively.
conclusionThese findings provide strong evidence to reinforce public health measures on preventing colorectal cancer that promote PA at a population level regardless of body fatness.
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