ArticleLeukemia2021
Germline variants drive myelodysplastic syndrome in young adults.
Open access · greenAbstract readLetter
In one paragraph
Article in Leukemia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Real-world investigation of germ line predisposition to myelodysplastic syndromes.Blood advances · 2026Article
- Article
- The global epidemiology of acute myeloid leukaemia.Nature reviews. Clinical oncology · 2026Review
- Article
- Overrepresentation of Germline Immune-Related Gene Variants in Patients with Acquired Bone Marrow Failure.Journal of clinical immunology · 2025Article
- Detecting likely germline variants during tumor-based molecular profiling.The Journal of clinical investigation · 2025Review
- Article
- Progress in the Genetics of Myelodysplastic Syndromes with a Latin American Perspective.Genes · 2025Review
- Myelodysplastic Neoplasms (MDS): Pathogenesis and Therapeutic Prospects.Biomolecules · 2025Review
- [Diagnostic approaches and clinical relevance of hereditary hematological malignancies].Magyar onkologia · 2025Review
- Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis inScience translational medicine · 2025Article
- Molecular pathophysiology of germline mutations in acute myeloid leukemia.International journal of hematology · 2024Review
- Prospective genetic germline evaluation in a consecutive group of adult patients aged <60 years with myelodysplastic syndromes.HemaSphere · 2024Article
- Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders.Best practice & research. Clinical haematology · 2024Review
- Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.Cancer discovery · 2024Article
- Special Issue "Advances in Molecular Pathogenesis and Targeted Therapies for Myeloid Neoplasms".International journal of molecular sciences · 2024Article
- Article
- Management of Patients with Lower-Risk Myelodysplastic Neoplasms (MDS).Current oncology (Toronto, Ont.) · 2023Review
- ERCC6L2-related disease: a novel entity of bone marrow failure disorder with high risk of clonal evolution.Annals of hematology · 2023Review
- Myelodysplastic Syndromes: New Methods of Diagnosis, Prognostication, and TreatmentDeutsches Arzteblatt international · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 16 institutions in 4 countries.
Simone FeursteinDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9996-4277
Jane E ChurpekDivision of Hematology, Medical Oncology, and Palliative Care, Department of Medicine, The University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Tom WalshDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.
Sioban KeelDepartment of Medicine, Division of Hematology, University of Washington, Seattle, WA, USA.
Marja HakkarainenApplied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3793-4803
Thomas SchroederDepartment of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany.
Ulrich GermingDepartment of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany.
Stefanie GeyhDepartment of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany.
Michael HeuserDepartment of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0001-5318-9044
Felicitas TholDepartment of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Christian PohlkampMunich Leukemia Laboratory, Munich, Germany.
Torsten HaferlachMunich Leukemia Laboratory, Munich, Germany.
Juehua GaoDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Carolyn OwenDivision of Hematology and Hematological Malignancies, University of Calgary, Calgary, AB, Canada.
Gudrun GoehringDepartment of Human Genetics, Hannover Medical School, Hannover, Germany.
Brigitte SchlegelbergerDepartment of Human Genetics, Hannover Medical School, Hannover, Germany.
Divij VermaGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Medicine, Frankfurt, Germany.
Daniela S KrauseGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Medicine, Frankfurt, Germany.ORCID http://orcid.org/0000-0003-3603-1119
Guimin GaoDepartment of Public Health Sciences, The University of Chicago, Chicago, IL, USA.
Tara CroninRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Suleyman GulsunerDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3897-1238
Ming LeeDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Colin C PritchardDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Hari Prasanna SubramanianDepartment of Human Genetics, The University of Chicago, Chicago, IL, USA.
Daniela Del GaudioDepartment of Human Genetics, The University of Chicago, Chicago, IL, USA.
Zejuan LiDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, TX, USA.
Soma DasDepartment of Human Genetics, The University of Chicago, Chicago, IL, USA.
Outi KilpivaaraApplied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ulla Wartiovaara-KauttoApplied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Eunice S WangRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID http://orcid.org/0000-0002-8644-0968
Elizabeth A GriffithsRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Konstanze DöhnerDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.
Hartmut DöhnerDepartment of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.
Mary-Claire KingDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Lucy A GodleyDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA. lgodley@medicine.bsd.uchicago.edu.ORCID http://orcid.org/0000-0003-1914-9158
University of Chicago · USUniversity of Washington · USMedizinische Hochschule Hannover · DEHeinrich Heine University Düsseldorf · DERoswell Park Comprehensive Cancer Center · USUniversity of Helsinki · FIMunich Leukemia Laboratory (Germany) · DEUniversity Hospital Ulm · DEAlbert Einstein College of Medicine · USChicago Department of Public Health · USGeorg Speyer Haus · DEMethodist Hospital · USNorthwestern University · USUniversity of Calgary · CAUniversity of Washington Medical Center · USUniversity of Wisconsin–Madison · US
Funding
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6MTranslational Studies of Inherited Marrow Failure and Myelodysplastic SyndromesR24DK099808 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ABKOWITZ, JANIS L, EBERT, BENJAMIN LEVINE · 2013 to 2017
$8.2MGENOMIC ANALYSIS OF INHERITED BREAST AND OVARIAN CANCERR35CA197458 · NCI · UNIVERSITY OF WASHINGTON · PI KING, MARY-CLAIRE · 2015 to 2021
$6.4MInflammation-Driven Clonal Evolution in RUNX1 Carriers: Mechanisms and Therapeutic VulnerabilitiesR01HL155426 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Anupriya Agarwal · 2021 to 2026
$2.7MMyeloid Malignancy Variant Curation Expert PanelU24CA258118 · NCI · UNIVERSITY OF CHICAGO · PI LUCY Ann GODLEY, David Wu · 2021 to 2026
$1.7MREVISION: Defining the mechanisms by which BRCA1 maintains genomic stability in hematopoiesisR03HL145253 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CHURPEK, JANE ELLEN · 2018 to 2019
$159kNCI NIH HHS P30 CA016056NCI NIH HHS R35 CA197458NCI NIH HHS U24 CA258118NHLBI NIH HHS R01 HL155426NHLBI NIH HHS R03 HL145253NIDDK NIH HHS R24 DK099808
Abstract
PubMed holds no abstract for this paper.
Indexed as
Genetic Predisposition to DiseaseGerm-Line MutationAdolescentAdultAnemia, AplasticBiomarkersFemaleHumansMaleMyelodysplastic SyndromesPrognosisYoung AdultBiomarkers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.