ArticleScientific reports2021
Lower values of a novel index of Vagal-Neuroimmunomodulation are associated to higher all-cause mortality in two large general population samples with 18 year follow up.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Rhythmic Skeletal Muscle Tension Increases Heart Rate Variability at 1 and 6 Contractions Per Minute.Applied psychophysiology and biofeedback · 2022Trial
- Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Autonomic-Immunoinflammatory-Cardiac Interplay during Lipopolysaccharide-Induced Systemic Inflammation.Neuroimmunomodulation · 2026Article
- Role of macrophages in neuroimmune regulation.Frontiers in immunology · 2025Review
- Do Longer Exhalations Increase HRV During Slow-Paced Breathing?Applied psychophysiology and biofeedback · 2024Article
- Determining the direction of prediction of the association between parasympathetic dysregulation and exhaustion symptoms.Scientific reports · 2022Article
- Prefrontally modulated vagal neuroimmunomodulation is associated with telomere length.Frontiers in neuroscience · 2022Article
- Wireless Heart Rate Variability in Assessing Community COVID-19.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In recent clinical practice, a biomarker of vagal neuroimmunomodulation (NIM), namely the ratio of vagally-mediated heart rate variability (vmHRV) and CRP, was proposed to index the functionality of the cholinergic anti-inflammatory pathway. This study aims to transfer and extend the previous findings to two general population-based samples to explore the hypothesis that NIM-ratio is associated with all-cause mortality. Two large population studies (MIDUS 2: N = 1255 and Whitehall II wave 5: N = 7870) with complete data from a total of N = 3860 participants (36.1% females; average age = 56.3 years; 11.1% deaths, last exit 18.1 years post inclusion) were available. NIM indices were calculated using the vagally-mediated HRV measure RMSSD divided by measures of CRP (NIM
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