ArticleScientific reports2021
Changes in headache characteristics with oral appliance treatment for obstructive sleep apnea.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Orofacial pain/headache interlaced to insomnia, sleep apnea and periodic limb movement during sleep/restless leg syndrome: a critical and comprehensive review with insights into social determinants.Journal of oral & facial pain and headache · 2025Review
- Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study.Nature and science of sleep · 2025Article
- Polysomnographic and clinical characteristics of sleep apnea headache patients.Sleep & breathing = Schlaf & Atmung · 2024Article
- Article
- Obstructive sleep apnea treatment improves temporomandibular disorder pain.Sleep & breathing = Schlaf & Atmung · 2024Article
- The role of oral appliance therapy in obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Prevalence and factors correlated with hypertension secondary from obstructive sleep apnea.Multidisciplinary respiratory medicine · 2021Article
- Pediatric Chronic Orofacial Pain: A Narrative Review of Biopsychosocial Associations and Treatment Approaches.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
- Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus.Frontiers in neurology · 2021Review
- Tapia's Syndrome following Noninvasive Continuous Positive Airway Pressure Therapy: A Case Report.Case reports in neurologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in headache characteristics in obstructive sleep apnea (OSA) patients following oral appliance treatment was investigated for the first time. Thirteen OSA patients with headaches treated with a mandibular advancement device were investigated. Level I polysomnography and Migraine Disability Assessment Questionnaire were completed before and after treatment. Various headache characteristics and concomitant conditions were analyzed. The patient was considered a headache responder when ≥ 30% reduction in headache frequency following treatment. Differences in headache and polysomnographic parameters were compared between headache responder groups. Eight patients (62%) were headache responders. Eleven patients (85%) before and 7 (54%) after treatment reported morning headaches. Significantly more patients had bilateral headache in the responder group before treatment (P = 0.035). The severest headache intensity (P = 0.018) at baseline showed a significant decrease in the headache responder group after treatment. The time spent in N2 (r = - 0.663, P = 0.014), REM sleep (r = 0.704, P = 0.007) and mean oxygen saturation (r = 0.566, P = 0.044) showed a significant correlation with post-treatment average headache intensity. Pre-treatment lower PLM index (r = - 0.632, P = 0.027) and higher mean oxygen saturation levels (r = 0.592, P = 0.043) were significantly correlated with higher post-treatment severest headache intensity. Treatment with an oral appliance is beneficial for many OSA patients with headaches. It should be considered as an alternative treatment in headache patients with mild to moderate OSA.
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