ArticleScientific reports2021
Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Article
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- Total Synthesis and Biological Profiling of Putative (±)-Marinoaziridine B and (±)-Marine drugs · 2024Article
- Synthesis and Biological Evaluations of Granulatamide B and its Structural Analogues.Current medicinal chemistry · 2024Article
- Bioprospecting of FivePharmaceuticals (Basel, Switzerland) · 2023Article
- Intra-Species Variations of Bioactive Compounds of Two Dictyota Species from the Adriatic Sea: Antioxidant, Antimicrobial, Dermatological, Dietary, and Neuroprotective Potential.Antioxidants (Basel, Switzerland) · 2023Article
- Assessing the Morphological and Behavioral Toxicity of Catechol Using Larval Zebrafish.International journal of molecular sciences · 2022Article
- In Vivo and In Vitro Antioxidant Activity of Less Polar Fractions ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Bioprospecting of Less-Polar Fractions ofMarine drugs · 2022Article
- The utility of alternative models in particulate matter air pollution toxicology.Current research in toxicology · 2022Article
- Less Polar Compounds and Targeted Antioxidant Potential (In Vitro and In Vivo) ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Zebrafish, an In Vivo Platform to Screen Drugs and Proteins for Biomedical Use.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Bioprospecting of Less-Polar Constituents from Endemic Brown MacroalgaMarine drugs · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amazonian wildfires in 2019 have raised awareness about rainforest burning due to increased emissions of particulate matter and carbon. In the context of these emissions, by-products of lignin thermal degradation (i.e. methoxyphenols) are often neglected. Methoxyphenols entering the atmosphere may form intermediates with currently unknown reaction mechanisms and toxicity. This study for the first time provides a comprehensive insight into the impact of lignin degradation products [guaiacol, catechol], and their nitrated intermediates [4-nitrocatechol, 4,6-dinitroguaiacol, 5-nitroguaiacol] on zebrafish Danio rerio. Results revealed 4-nitrocatechol and catechol as the most toxic, followed by 4,6DNG > 5NG > GUA. The whole-organism bioassay integrated with molecular modeling emphasized the potential of methoxyphenols to inhibit tyrosinase, lipoxygenase, and carbonic anhydrase, consequently altering embryonic development (i.e. affected sensorial, skeletal, and physiological parameters, pigmentation formation failure, and non-hatching of larvae). The whole-organism bioassay integrated with in silico approach confirmed the harmful effects of lignin degradation products and their intermediates on aquatic organisms, emphasizing the need for their evaluation within ecotoxicity studies focused on aquatic compartments.
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