Evidence map›Paper›PMID 33510223›Full record

ArticleScientific reports2021

Assessment of the biological potential of diaryltriazene-derived triazene compounds.

Patricia de Maria Silva Figueirêdo, José Costa Sampaio Filho, Alzirene de Jesus Sales Sodré, José Ribamar de Castro Júnior, Ingrid Santos Gonçalves, Rodrigo Vieira Blasques, Rodrigo S Correa, Benedicto Augusto Vieira Lima, Larissa Dos Anjos Marques, Denise Fernandes Coutinho and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Novel Triazeneindole Antibiotics: Synthesis and Hit-to-Lead Optimization.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Patricia de Maria Silva FigueirêdoLaboratório de Microbiologia Clínica, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil.
José Costa Sampaio FilhoElectrochemistry and Biotechnology Laboratory (EBL), University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil.
Alzirene de Jesus Sales SodréLaboratório de Microbiologia Clínica, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil.
José Ribamar de Castro JúniorLaboratório de Microbiologia Clínica, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil.
Ingrid Santos GonçalvesElectrochemistry and Biotechnology Laboratory (EBL), University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil.
Rodrigo Vieira BlasquesDepartment of Nature Sciences, Mathematics, and Education, Federal University of São Carlos, Araras, SP, 13.600-970, Brazil.
Rodrigo S CorreaInstituto de Ciências Exatas e Biológicas (ICEB), Federal University of Ouro Preto (UFOP), Ouro Preto, MG, 35.400-000, Brazil.
Benedicto Augusto Vieira LimaLicenciatura em Ciências Naturais, Federal University of Maranhão (UFMA), Grajaú, MA, 65.940-000, Brazil.
Larissa Dos Anjos MarquesLaboratório de Microbiologia Clínica, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil.
Denise Fernandes CoutinhoLaboratório de Farmacognosia, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil.
Ana Paula Silva de Azevedo Dos SantosLaboratório de Imunologia Aplicada ao Câncer (LIAC), Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil.
Tássio Rômulo Silva Araújo LuzLaboratório de Farmacognosia, Federal University of Maranhão (UFMA), São Luís, MA, 65.080-040, Brazil.
Rita de Cassia Mendonça de MirandaElectrochemistry and Biotechnology Laboratory (EBL), University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil.
Julliana Ribeiro Alves Dos SantosLaboratory of Environmental Microbiology, University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil.
Antonio Carlos DoriguettoInstitute of Chemistry, Federal University of Alfenas (UNIFAL), Alfenas, MG, 37.130-001, Brazil.
María Isabel PividoriGrup de Sensors i Biosensors, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
Manfredo HörnerDepartment of Chemistry, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97.110-900, Brazil.
Paulo Cesar Mendes VillisElectrochemistry and Biotechnology Laboratory (EBL), University of CEUMA (UNICEUMA), São Luís, MA, 65.065-470, Brazil. paulo.villis@ceuma.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, novel, 1,3-diaryltriazene-derived triazene compounds were synthesized and tested. Triazenes are versatile and belong to a group of alkylating agents with interesting physicochemical properties and proven biological activities. This study describes the synthesis, molecular and crystalline structure, biological activity evaluation, and antifungal and antimicrobial potentials of 1,3-bis(X-methoxy-Y-nitrophenyl)triazenes [X = 2 and 5; Y = 4 and 5]. The antimicrobial and antifungal activities of the compounds were tested by evaluating the sensitivity of bacteria (American Type Culture Collection, ATCC) and clinical isolates to their solutions using standardized microbiological assays, cytotoxicity evaluation, and ecotoxicity tests. The antimicrobial potentials of triazenes were determined according to their minimum inhibitory concentrations (MICs); these compounds were active against gram-positive and gram-negative bacteria, with low MIC values. The most surprising result was obtained for T3 having the effective MIC of 9.937 µg/mL and antifungal activity against Candida albicans ATCC 90028, C. parapsilosis ATCC 22019, and C. tropicallis IC. To the best of our knowledge, this study is the first to report promising activities of triazene compounds against yeast and filamentous fungi. The results showed the potential utility of triazenes as agents affecting selected resistant bacterial and fungal strains.

Indexed as

Anti-Infective AgentsAntineoplastic AgentsDose-Response Relationship, DrugMicrobial Sensitivity TestsModels, MolecularMolecular StructureStructure-Activity RelationshipTriazenesAnti-Infective AgentsAntineoplastic AgentsTriazenes

Identifiers

PMID33510223
PMCPMC7844262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.