ArticleScientific reports2021
Acute environmental temperature variation affects brain protein expression, anxiety and explorative behaviour in adult zebrafish.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of Chronic Low-Temperature Exposure on the Behaviour of Adult Zebrafish (Animals : an open access journal from MDPI · 2026Article
- Proteomic Profiling Reveals Region-Specific Brain Responses During Acclimation to Elevated Water Temperature in Atlantic Salmon (Proteomes · 2026Article
- BDNF Deficiency Preserves Shoal Structure but Selectively Modulates Horizontal Exploration in an Adult BDNFInternational journal of molecular sciences · 2026Article
- Higher temperatures distinctly affect the brain mitochondrial respiration of two Amazonian fishes, a predator and a prey.Fish physiology and biochemistry · 2026Article
- Blood levels of D-aspartate oxidase, D-amino acid oxidase, serine racemase, and pLG72 are influenced by diagnoses of schizophrenia and autism spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2026Article
- Post-translational regulation of human D-3-phosphoglycerate dehydrogenase in Alzheimer's disease.Protein science : a publication of the Protein Society · 2026Article
- Behavioral, physiological, encephalopathological alterations and endoplasmic reticulum stress/apoptotic-related gene transcription in reaction to heat stress in Oreochromis niloticus fish: impact of dietary supplements with Spirulina-Coenzyme Q10 nanoemulsion.Veterinary research communications · 2026Article
- Chronic environmental temperature affects protein expression in the eye of adult zebrafish (Danio rerio).Scientific reports · 2025Article
- Heat-Stressed Brains: Epigenetic and Mitochondrial Signatures in Zebrafish.Molecular neurobiology · 2025Article
- Long-Term Heat Stress Triggers Immune Activation and Cell Death Remodeling in the Brain of Largemouth Bass (Animals : an open access journal from MDPI · 2025Article
- Early-Life Heat Stress Impairs Cognition and Alters Its Covariation With Behaviour in Zebrafish.Ecology and evolution · 2025Article
- Effects of Environmental Temperature Variation on the Spatio-Temporal Shoaling Behaviour of Adult Zebrafish (Animals : an open access journal from MDPI · 2025Article
- Housing and husbandry factors affecting zebrafish novel tank test responses: a global multi-laboratory study.Lab animal · 2025Article
- Heat Acclimation Enhances Brain Resilience to Acute Thermal Stress inAnimals : an open access journal from MDPI · 2025Article
- Association of Exposure to Humidex with Schizophrenia Admissions in Qingdao, China: A Time-Series Study.Neuropsychiatric disease and treatment · 2025Article
- Refinement of the novel tank diving test: toward standardized and robust analysis of anxiety-like behavior in zebrafish.Frontiers in behavioral neuroscience · 2025Article
- Impact of a teat disinfectant based on Lactococcus cremoris on the cow milk proteome.BMC veterinary research · 2024Article
- Environmental Temperature Variation Affects Brain Lipid Composition in Adult Zebrafish (International journal of molecular sciences · 2024Article
- Standardizing zebrafish laboratory husbandry to ensure replicability and reproducibility of data in neurobehavioral research.Lab animal · 2024Article
- The Neurotoxic Effect of Environmental Temperature Variation in Adult Zebrafish (International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the effect of 4-d acute thermal treatments at 18 °C, 26 °C (control) and 34 °C on the nervous system of adult zebrafish (Danio rerio) using a multidisciplinary approach based on behavioural tests and brain proteomic analysis. The behavioural variations induced by thermal treatment were investigated using five different tests, the novel tank diving, light and dark preference, social preference, mirror biting, and Y-Maze tests, which are standard paradigms specifically tailored for zebrafish to assess their anxiety-like behaviour, boldness, social preference, aggressiveness, and explorative behaviour, respectively. Proteomic data revealed that several proteins involved in energy metabolism, messenger RNA translation, protein synthesis, folding and degradation, cytoskeleton organisation and synaptic vesiculation are regulated differently at extreme temperatures. The results showed that anxiety-like behaviours increase in zebrafish at 18 °C compared to those at 26 °C or 34 °C, whereas anxiety-related protein signalling pathways are downregulated. Moreover, treatments at both 18 °C and 34 °C affect the exploratory behaviour that appears not to be modulated by past experiences, suggesting the impairment of fish cognitive abilities. This study is the continuation of our previous work on the effect of 21-d chronic treatment at the same constant temperature level and will enable the comparison of acute and chronic treatment effects on the nervous system function in adult zebrafish.
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