Evidence map›Paper›PMID 33510174›Full record

SynthesisNature communications2021

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.

Garan Jones, Katerina Trajanoska, Adam J Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L Atkins, Joshua R Lewis, ThuyVy Duong, Shengjun Hong, Mary L Biggs and 56 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 6 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 6 syntheses or guidelines pooled it, 217 citations in OpenAlex.

  1. Pooled it
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  14. MST4 as a key driver of osteoclast activation in osteoporosis.Journal of pharmaceutical analysis · 2026
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

66 authors at 20 institutions in 10 countries.

Garan Jones *Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.ORCID http://orcid.org/0000-0002-8917-3930
Katerina Trajanoska *Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3792-4296
Adam J Santanasto *University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-6912-2909
Najada Stringa *Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6350-452X
Chia-Ling Kuo *Biostatistics Center, Connecticut Convergence Institute for Translation in Regenerative Engineering, UConn Health, Farmington, CT, USA.
Janice L Atkins *Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.ORCID http://orcid.org/0000-0003-4919-9068
Joshua R LewisSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.ORCID http://orcid.org/0000-0003-1003-8443
ThuyVy DuongMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shengjun HongLübeck Interdisciplinary Plattform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.
Mary L BiggsCardiovascular Health Research Unit, Department of Medicine, and Department of Biostatistics, University of Washington, Seattle, WA, USA.
Jian'an LuanMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-3137-6337
Chloe SarnowskiBiostatistics Department, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6090-7099
Kathryn L LunettaBiostatistics Department, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9268-810X
Toshiko TanakaLongitudinal Study Section, Translational Gerontology branch, National Institute on Aging, Baltimore, MD, USA.
Mary K WojczynskiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Ryan CvejkusUniversity of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-5287-5341
Maria NethanderCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0003-3688-906X
Sahar GhasemiDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Jingyun YangRush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3495-3710
M Carola ZillikensDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Stefan WalterDepartment of Medicine and Public Health, Rey Juan Carlos University, Madrid, Spain.ORCID http://orcid.org/0000-0002-6010-7550
Kamil SicinskiCenter for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.
Erika KagueSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-0266-9424
Cheryl L Ackert-BicknellDepartment of Orthopedics, University of Colorado, Aurora, CO, USA.
Dan E ArkingMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
B Gwen WindhamDepartment of Medicine/Geriatrics, University of Mississippi School of Medicine, Jackson, MS, USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Megan L GroveHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Misa GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.ORCID http://orcid.org/0000-0001-6380-1735
Dominik SpiraCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Ilja DemuthCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Nathalie van der VeldeDepartment of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Lisette C P G M de GrootWageningen University, Division of Human Nutrition, PO-box 17, 6700 AA, Wageningen, The Netherlands.ORCID http://orcid.org/0000-0003-2778-2789
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health services, University of Washington, Seattle, WA, USA.
Michelle C OddenDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.
Alison E FohnerDepartment of Epidemiology and Institute of Public Genetics, University of Washington, Seattle, WA, USA.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0002-5017-7344
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-1422-2993
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Natasja M van SchoorDepartment of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Martijn HuismanDepartment of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Qihua TanEpidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0003-3194-0030
Joseph ZmudaUniversity of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA.
Dan MellströmCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Magnus KarlssonClinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
David A BennettRush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Aron S BuchmanRush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-6426-2742
Philip L De JagerCenter for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8057-2505
Andre G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-5689-3448
Thomas KocherDepartment of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-9605-2822
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Leocadio Rodriguéz-MañasCIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
Francisco J GarcíaCIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
José A CarniceroCIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
Pamela HerdProfessor of Public Policy, Georgetown University, Washington, DC, USA.
Lars BertramLübeck Interdisciplinary Plattform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-0108-124X
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Joanne M MurabitoSection of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA.
David MelzerEpidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.ORCID http://orcid.org/0000-0002-0170-3838
George A KuchelCenter on Aging, University of Connecticut Health, 263 Farmington Avenue, Farmington, CT, 06030, USA.ORCID http://orcid.org/0000-0001-8387-7040
Luigi FerrucciNational Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6273-1613
David KarasikMarcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8826-0530
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Douglas P KielMarcus Institute for Aging Research, Hebrew SeniorLife and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Broad Institute of MIT & Harvard, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8474-0310
Luke C PillingEpidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. L.Pilling@exeter.ac.uk.ORCID http://orcid.org/0000-0002-3332-8454
Erasmus MC · NLUniversitätsmedizin Greifswald · DEUniversity of Exeter · GBAmsterdam University Medical Centers · NLBoston University · USRush University Medical Center · USUniversity of Cambridge · GBUniversity of Pittsburgh · USBroad Institute · USHumboldt-Universität zu Berlin · DEJohns Hopkins University · USNational Institute on Aging · USUConn Health · USUniversity of Gothenburg · SEUniversity of Lübeck · DEUniversity of Washington · USAmsterdam UMC Location University of Amsterdam · NLAzienda Sanitaria di Firenze · ITBar-Ilan University · ILBaylor College of Medicine · US

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
The Aging Genome Association Study "AGE-GAIN"ZIAAG000965 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$4.0M
The InChianti StudyZIAAG001050 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$2.1M
Training in Molecular Epidemiology: Linking Genes to Physical Function in Older AdultsK01AG057726 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANTANASTO, ADAM J · 2018 to 2022
$582k
Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_12015/1Medical Research Council MR/M008924/1Medical Research Council MR/M023095/1NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS K01 AG057726NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917
6 · The paper itself

Abstract

Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and over from 22 cohorts we identify 15 loci associated with muscle weakness (European Working Group on Sarcopenia in Older People definition: n = 48,596 cases, 18.9% of total), including 12 loci not implicated in previous analyses of continuous measures of grip strength. Loci include genes reportedly involved in autoimmune disease (HLA-DQA1 p = 4 × 10

Indexed as

AgedAged, 80 and overAgingCohort StudiesEuropeFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGrowth Differentiation Factor 5HLA-DQ alpha-ChainsHumansMaleMiddle AgedMuscle StrengthMuscle WeaknessPolymorphism, Single NucleotideGDF5 protein, humanGrowth Differentiation Factor 5HLA-DQA1 antigenHLA-DQ alpha-Chains

Identifiers

PMID33510174
PMCPMC7844411
OpenAlexW3122693493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.