ArticleRMD open2021
Normal salivary gland ultrasonography could rule out the diagnosis of Sjögren's syndrome in anti-SSA-negative patients with sicca syndrome.
Article in RMD open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.Rheumatology (Oxford, England) · 2025Guideline
- Ultra-high frequency ultrasound of labial salivary glands in Sjögren's disease: diagnostic accuracy and patient stratification.RMD open · 2026Article
- Article
- Diagnostic concordance and added value of doppler ultrasound and extended histopathologic features in primary Sjögren disease.Clinical rheumatology · 2026Article
- Integrative Bioinformatics and Machine Learning Identify Novel Diagnostic Biomarkers and Molecular Mechanisms in Sjögren's Syndrome.International journal of genomics · 2026Article
- The agreement of the OMERACT grey-scale ultrasound scoring system for salivary glands and minor salivary gland biopsy results in a single-center cohort of patients with suspected Sjögren's disease.Skeletal radiology · 2025Article
- Agreement between glandular ultrasonography and histopathology of minor salivary glands in adults with sicca syndrome.Clinical rheumatology · 2025Article
- The diagnostic value and clinical relevance of salivary gland ultrasound in patients with highly suspected Sjögren's Disease: a prospective monocentric study.Arthritis research & therapy · 2025Article
- Value of combined application of the OMERACT scoring system and shear wave elastography for primary Sjögren's syndrome.Clinical rheumatology · 2025Article
- The value of parotid sialography in the diagnosis and staging of Sjogren's syndrome.Journal of dental sciences · 2024Article
- The Role of Major Salivary Gland Ultrasound in the Diagnostic Workup of Sicca Syndrome: A Large Single-Centre Study.Tomography (Ann Arbor, Mich.) · 2024Article
- Ultrasonography in the diagnosis of suspected primary Sjögren's syndrome and concordance with salivary gland biopsy: a Spanish single-center study.Clinical rheumatology · 2023Article
- [Diagnostic performances of salivary gland ultrasonography for Sjögren's syndrome].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Article
- "All that glitters is not gold": sialomegaly, xerostomia, and dry eye is not always Sjögren's syndrome.Reumatologia · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the relevance of salivary gland ultrasound (SGUS) and its place in the diagnostic algorithm in patients referred with dry syndrome (DS) for a suspicion of Sjögren's syndrome (SS).
methodsWe included all patients assessed at our dedicated DS clinic from June 2015 to September 2019 for which a SGUS has been carried out. Images were read blindly and the worst salivary gland was scored according to OMERACT classification. Clinical features, disease activity and treatments were collected.
results337 patients were seen from June 2015 to September 2019. 269 patients underwent SGUS. 77 patients were diagnosed with SS and 192 did not meet the ACR/EULAR criteria for SS: non-Sjögren's DS (NSDS). Of these 192 patients, 60 had another possible cause of DS, and 132 patients were diagnosed with SAPS (sicca, asthenia, polyalgia syndrome).SGUS abnormalities were significantly higher in patients with SS versus NSDS: 51% vs 8% for a score ≥2 (p<0.0001), and 43% vs 3% for a score ≥3 (p<0.0001). SGUS score ≥2 had a specificity (Sp) of 91%, sensitivity (Se) of 57%, positive predictive value (PPV) of 72% and negative predictive value (NPV) of 82% for SS diagnosis. SGUS's characteristics in SSA-negative patients were similar to the whole population (Se=42%, Sp=91%, PPV=42%, NPV=92%). The high specificity and NPV in this population could avoid labial salivary gland biopsy (LSGB) in SSA-negative patients with normal SGUS (186 patients, 69%).
conclusionSGUS is useful for SS diagnosis. If anti-SSA antibodies are negative and SGUS score <2, the diagnosis of SS is very improbable and LSGB could be avoided.
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