Evidence map›Paper›PMID 33509976›Full record

ArticleHeart (British Cardiac Society)2021

Atrial fibrillation prevalence, awareness and management in a nationwide survey of adults in China.

Xin Du, Lizhu Guo, Shijun Xia, Jing Du, Craig Anderson, Hisatomi Arima, Mark Huffman, Yiqiang Yuan, Yang Zheng, Shulin Wu and 6 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Heart (British Cardiac Society), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 104 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06307860 unknown statusnot on this mapstarted 2022, after this paper: background citation

Comparison of Pulse Field Ablation and Radiofrequency Ablation in Left Atrial Reverse Remodeling in Patients With Paroxysmal Atrial Fibrillation

TypeobservationalSponsorYun WanRan2022 to 2025Enrolled120ConditionsAtrial FibrillationArmspulsed field ablation, radiofrequency ablation
NCT07320768 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

The Efficacy and Safety of Renal Denervation Combined With Pulsed Field Ablation in Preventing Recurrence of Atrial Arrhythmia in Patients With Persistent Atrial Fibrillation: An OFF-MED Trial

TypeinterventionalSponsorShanghai Chest HospitalRan2026 to 2027Enrolled86ConditionsPersistent Atrial FibrillationArmsrenal denervation, Pulsed-Field Ablation (PFA)
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. The Fibrillatory Wave Amplitude of ECG Decreases Over Time in Patients With Persistent AF: A Retrospective Cohort Study.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xin DuBeijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.
Lizhu GuoBeijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.
Shijun XiaBeijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.
Jing DuBeijing Center for Disease Prevention and Control, Beijing, China.
Craig AndersonHeart Health Research Centre, Beijing, China.
Hisatomi ArimaDepartment of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Mark HuffmanNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Yiqiang YuanThe Seventh People's Hospital of Zhengzhou, Zhengzhou, China.
Yang ZhengDepartment of Cardiology, The First Hospital of Jilin University, Changchun, China.
Shulin WuDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xuefeng GuangDepartment of Cardiology, Yanan Hospital of Kunming, Kunming, China.
Xianhui ZhouDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, China.
Hongbo LinYinzhou District Center for Disease Control and Prevention, Ningbo, China.
Xiaoshu ChengCardiovascular Department, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jianzeng DongBeijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.
Changsheng MaBeijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China chshma@vip.sina.com.ORCID http://orcid.org/0000-0002-5387-5957

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine AF prevalence and gaps in atrial fibrillation (AF) awareness and management in China.

methodsWe conducted a community-based survey of 47 841 adults (age ≥45 years) in seven geographic regions of China between 2014 and 2016. Participants underwent a structured questionnaire, a standard 12-lead ECG, physical examination and blood sampling. AF prevalence, defined by either ECG detection or self-report, was estimated according to sampling weights, non-response and age and sex distribution of the population. We used multivariable logistic regression to estimate associations among sociodemographic, clinical and geographic factors with the AF prevalence, awareness and treatment.

resultsThe weighted AF prevalence was 1.8% (95% CI 1.7% to 1.9%), but varied from 0.9% to 2.4% across geographical regions and equates to being present in an estimated 7.9 (95% CI 7.4 to 8.4) million people in China. Among men and women, the AF prevalence increased from 0.8% and 0.6% in the age group 45-54 years to 5.4% and 4.9% in the age group ≥75 years, respectively. Proportions of people who were aware of having AF decreased overall from 65.3% in 45-54 year-olds to 53.9% in ≥75 year-olds and varied between sex (men 58.5%, women 68.8%) and residency status (urban 78.3%, rural 35.3%). Only 6.0% of patients with high-risk AF received anticoagulation therapy.

conclusionsAF prevalence is higher than previously reported in China, with low awareness and large treatment gaps. Large-scale efforts are urgently needed to reduce AF adverse consequences.

Indexed as

atrial fibrillationepidemiology

Identifiers

PMID33509976
PMCPMC7958113

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.