Evidence map›Paper›PMID 33509952›Full record

ArticleeNeuro

Temporal Contrast Sensitivity Increases despite Photoreceptor Degeneration in a Mouse Model of Retinitis Pigmentosa.

Rose L Pasquale, Ying Guo, Yumiko Umino, Barry Knox, Eduardo Solessio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rose L PasqualeDepartment of Ophthalmology and Visual Sciences, Center for Vision Research, State University of New York Upstate Medical University, Syracuse, NY 13210.
Ying GuoDepartment of Ophthalmology and Visual Sciences, Center for Vision Research, State University of New York Upstate Medical University, Syracuse, NY 13210.
Yumiko UminoDepartment of Ophthalmology and Visual Sciences, Center for Vision Research, State University of New York Upstate Medical University, Syracuse, NY 13210.
Barry KnoxDepartment of Ophthalmology and Visual Sciences, Center for Vision Research, State University of New York Upstate Medical University, Syracuse, NY 13210.
Eduardo SolessioDepartment of Ophthalmology and Visual Sciences, Center for Vision Research, State University of New York Upstate Medical University, Syracuse, NY 13210 solessie@upstate.edu.
SUNY Upstate Medical University · US

Funding

Contribution of rod photoresponse inactivation kinetics to visual temporal contrast sensitivity in mesopic light.R01EY026216 · NEI · UPSTATE MEDICAL UNIVERSITY · PI SOLESSIO, EDUARDO C · 2016 to 2025
$3.5M
NEI NIH HHS R01 EY026216
6 · The paper itself

Abstract

The detection of temporal variations in amplitude of light intensity, or temporal contrast sensitivity (TCS), depends on the kinetics of rod photoresponse recovery. Uncharacteristically fast rod recovery kinetics are facets of both human patients and transgenic animal models with a P23H rhodopsin mutation, a prevalent cause of retinitis pigmentosa (RP). Here, we show that mice with this mutation (Rho

Indexed as

Retinal DegenerationRetinitis PigmentosaAnimalsContrast SensitivityDisease Models, AnimalElectroretinographyHumansMiceRhodopsinRhodopsinmouse modelP23Hretinitis pigmentosarhodopsinrod photoreceptorstemporal contrast sensitivity

Identifiers

PMID33509952
PMCPMC8059883
OpenAlexW3122826968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.