Evidence map›Paper›PMID 33509917›Full record

ArticleAJNR. American journal of neuroradiology2021

Real-Time Ultrasound Image Fusion with FDG-PET/CT to Perform Fused Image-Guided Fine-Needle Aspiration in Neck Nodes: Feasibility and Diagnostic Value.

P K de Koekkoek-Doll, M Maas, W Vogel, J Castelijns, L Smit, I Zavrakidis, R Beets-Tan, M van den Brekel

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. ISUOG/ESGO Consensus Statement on ultrasound-guided biopsy in gynecological oncology.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Guideline
  2. Article
  3. Article
  4. Article
  5. SUVAmerican journal of nuclear medicine and molecular imaging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

P K de Koekkoek-DollFrom the Departments of Radiology (P.K.d.K.-D., M.M., J.C., R.B.-T.) p.doll@nki.nl.ORCID 0000-0001-9370-6026
M MaasFrom the Departments of Radiology (P.K.d.K.-D., M.M., J.C., R.B.-T.).ORCID 0000-0001-7721-2341
W VogelNuclear Medicine (W.V.).ORCID 0000-0002-4992-8024
J CastelijnsFrom the Departments of Radiology (P.K.d.K.-D., M.M., J.C., R.B.-T.).ORCID 0000-0001-5105-4023
L SmitPathology (L.S.).ORCID 0000-0003-1325-4790
I ZavrakidisEpidemiology and Biostatistics (I.Z.), Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID 0000-0002-5034-865X
R Beets-TanFrom the Departments of Radiology (P.K.d.K.-D., M.M., J.C., R.B.-T.).ORCID 0000-0002-8533-5090
M van den BrekelHead and Neck Surgery and Oncology (M.v.d.B.).ORCID 0000-0002-6338-6743
Neurology, Inc · USAmsterdam UMC Location University of Amsterdam · NLInstitute of Nuclear Physics · UZL-3 Communications (United States) · USNorwegian Womens Public Health Association · NOThe Netherlands Cancer Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeNew imaging techniques such as hybrid imaging of ultrasound and FDG-PET/CT are available but not yet investigated for node staging. The aim of the study was to evaluate the feasibility and added diagnostic value of real-time image-fused ultrasound-guided fine-needle aspiration with FDG-PET/CT data for node staging. MATERIALS AND

methodsNinety-six patients who were referred for cervical lymph node staging with FDG-PET/CT before ultrasound were prospectively included. After routine ultrasound-guided fine-needle aspiration, all FDG-PET-positive nodes were marked on FDG-PET/CT, and real-time image fusing of ultrasound and FDG-PET/CT was performed using the electromagnetic navigation system PercuNav. Already-punctured nodes were confirmed to be PET-positive, and additional fused-ultrasound-guided fine-needle aspiration was performed in previously missed PET-positive nodes.

resultsOf 96 patients, 87 (91%) patients had suspicious nodes requiring fine-needle aspiration cytology. Ultrasound-guided fine-needle aspiration was performed in 175 nodes. Cytology was inconclusive in 9/175 (5%) nodes, and 85/166 (51%) nodes were malignant. Target planning was performed in 201 PET-positive nodes; 195/201 (97%) of those nodes were fused successfully. Twenty of 175 ultrasound-guided fine-needle aspiration nodes turned out to be FDG-PET-negative, and 149/175 (85%) of the fused ultrasound-guided fine-needle aspiration nodes were confirmed to be FDG-PET-positive. Of 201 PET-positive nodes, 46 (23%) were additionally identified, and fused ultrasound-guided fine-needle aspiration was performed. Cytology was inconclusive in 4/46 nodes (9%), and 13/42 (31%) nodes were malignant.

conclusionsReal-time ultrasound image fusion with FDG-PET-positive nodes is feasible in cervical lymph nodes, and fused ultrasound-guided fine-needle aspiration increases the number of malignant nodes detected.

Indexed as

AdultAgedBiopsy, Fine-NeedleFeasibility StudiesFemaleFluorodeoxyglucose F18HumansImage-Guided BiopsyLymphatic MetastasisMaleMiddle AgedMultimodal ImagingNeoplasm StagingPositron Emission Tomography Computed TomographyUltrasonographyYoung AdultFluorodeoxyglucose F18

Identifiers

PMID33509917
PMCPMC7959435
OpenAlexW3125435240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.