Evidence map›Paper›PMID 33509807›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2021

The Role of Forkhead Box Q1 Transcription Factor in Anticancer Effects of Withaferin A in Breast Cancer.

Su-Hyeong Kim, Krishna B Singh, Eun-Ryeong Hahm, Shivendra V Singh

Open access · bronzeAbstract read
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors.Cancer prevention research (Philadelphia, Pa.) · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Su-Hyeong KimDepartment of Pharmacology & Chemical Biology, Pittsburgh, Pennsylvania.
Krishna B SinghDepartment of Pharmacology & Chemical Biology, Pittsburgh, Pennsylvania.
Eun-Ryeong HahmDepartment of Pharmacology & Chemical Biology, Pittsburgh, Pennsylvania.
Shivendra V SinghDepartment of Pharmacology & Chemical Biology, Pittsburgh, Pennsylvania. singhs@upmc.edu.
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Breast Cancer Prevention by Ayurvedic Medicine ConstituentsR01CA142604 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SINGH, SHIVENDRA · 2010 to 2019
$3.2M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA142604
6 · The paper itself

Abstract

Elimination of both rapidly dividing epithelial mammary cancer cells as well as breast cancer stem-like cells (bCSC) is essential for maximizing antitumor response. Withaferin A (WA), a small molecule derived from a medicinal plant (

Indexed as

ApoptosisBreast NeoplasmsCell ProliferationFemaleForkhead Transcription FactorsGene Expression Regulation, NeoplasticHumansNeoplastic Stem CellsTumor Cells, CulturedWithanolidesForkhead Transcription FactorsFOXQ1 protein, humanwithaferin AWithanolides

Identifiers

PMID33509807
PMCPMC8026678
OpenAlexW3122320636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.