ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021
[A non-invasive method for detecting mitochondrial tRNA
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
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4 authors at 1 institution in 1 country.
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Abstract
objectiveTo explore the feasibility of detecting maternal hereditary mitochondrial tRNA
methodsWe performed sequence analysis of mitochondrial DNA in blood samples from 2070 cases of maternal hereditary mitochondrial disease in the First Affiliated Hospital of Wenzhou Medical University, and identified 3 patients with m.15927G>A mutation.Buccal swabs and blood samples were obtained from the 3 patients (mutation group) and 3 normal volunteers (control group).After extracting whole genomic DNA from all the samples, the DNA concentration and purity were analyzed.The PCR products were subjected to dot blot hybridization, Southern blot hybridization, and DNA sequencing analysis to verify the feasibility of detecting m.15927G>A mutation using buccal swabs.
resultsThere was no significant difference in DNA concentration extracted from buccal swabs and blood samples in either the mutation group or the control group (
conclusionsBuccal swabs collection accurate is an accurate and sensitive method for the detection of m.15927G>A mutation.
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