Evidence map›Paper›PMID 33509753›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021

[Pathogenic role of NDUFA13 inactivation in spontaneous hepatitis in mice and the mechanism].

Xiaohui Xu, Rui Li, Xin Zeng, Xin Wang, Bingqian Xue, Daochao Huang, Yi Huang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. [Adeno-associated virus-mediated hepatocyte-specific NDUFA13 overexpression protects against CClNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaohui XuInstitute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity// Key Laboratory of Child Development and Disorders of Ministry of Education//National Clinical Research Center for Child Health and Disorders//China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China.
Rui LiInstitute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity// Key Laboratory of Child Development and Disorders of Ministry of Education//National Clinical Research Center for Child Health and Disorders//China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China.
Xin ZengInstitute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity// Key Laboratory of Child Development and Disorders of Ministry of Education//National Clinical Research Center for Child Health and Disorders//China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China.
Xin WangInstitute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity// Key Laboratory of Child Development and Disorders of Ministry of Education//National Clinical Research Center for Child Health and Disorders//China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China.
Bingqian XueInstitute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity// Key Laboratory of Child Development and Disorders of Ministry of Education//National Clinical Research Center for Child Health and Disorders//China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China.
Daochao HuangInstitute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity// Key Laboratory of Child Development and Disorders of Ministry of Education//National Clinical Research Center for Child Health and Disorders//China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China.
Yi HuangInstitute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Infection and Immunity// Key Laboratory of Child Development and Disorders of Ministry of Education//National Clinical Research Center for Child Health and Disorders//China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China.
China International Science and Technology Cooperation · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the role of NDUFA13 inactivation in the pathogenesis of spontaneous hepatitis in mice and explore the possible mechanisms.

methodsHepatocyte-specific NDUFA13 knockout (NDUFA13

resultsLiver-specific NDUFA13 heterozygous knockout mice were successfully constructed as verified by PCR results. HE staining revealed severe liver damage in both 4- week-old and 2-year-old NDUFA13

conclusionsHepatocytes-specific NDUFA13 ablation can trigger spontaneous hepatitis in mice possibly mediated by the activation of ROS/NF-κB/NLRP3 signaling.

Indexed as

HepatitisNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsInflammasomesMiceNF-kappa BSignal TransductionInflammasomesNF-kappa BNLR Family, Pyrin Domain-Containing 3 Proteingene knockout mice modelNDUFA13NLRP3spontaneous hepatitis

Identifiers

PMID33509753
PMCPMC7867491
OpenAlexW3123546469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.