ReviewTrends in cognitive sciences2021
Cognition in the Chronic Pain Experience: Preclinical Insights.
Review in Trends in cognitive sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence for Cognitive Decline in Chronic Pain: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2021Pooled it
- Wireless IoT-enabled microneedle electroceutical for personalized and connected pain management.Nature communications · 2026Article
- Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects.Nature communications · 2026Article
- Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study.European journal of pain (London, England) · 2026Observational
- Chronic Pain and Cognitive Dysfunction: Clinical Implement, Mechanism, and Therapeutic Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- A top-down neural circuit for affective-motivational responses of pain relief induced by electroacupuncture.Chinese medicine · 2026Article
- Early-Life War Exposure and Later-Life Chronic Pain in Vietnam: Risk, Resilience, and Timing.Journal of health and social behavior · 2026Article
- A Comprehensive Mendelian Randomization Study of Bidirectional Causal Relationships Between Pain and Mental Disorders.Journal of pain research · 2026Article
- Hypoactivity of the prelimbic cortex projecting to the lateral entorhinal cortex contributes to neuropathic pain-induced object recognition memory impairment in mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Unravelling the Connection Between Reduced Mobility and Mild Cognitive Impairment in Chronic Pain Patients Through Cluster Analysis.Advances in experimental medicine and biology · 2026Article
- Effects of Music Intervention on Pain, Mood, Sleep, and Heart Rate Variability in Patients with Chronic Pain: A Randomized Controlled Trial.Journal of pain research · 2026Article
- Differential associations of non-chronic and chronic pain with dementia risk: insights from a cohort study.Frontiers in neuroscience · 2026Article
- Cognitive Domain Impairments in Chronic Painful Temporomandibular Disorders: Associations With Pain Intensity, Hypervigilance and Catastrophising: A Cross-Sectional Analysis.Journal of oral rehabilitation · 2026Article
- Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain-Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- [What does pain have to do with neuronal networks and the afferent matrix?]Orthopadie (Heidelberg, Germany) · 2025Review
- Eating to Feel Better: The Role of Comfort Eating in Chronic Pain.Journal of clinical psychology in medical settings · 2025Article
- Possible Anti-Pain Vaccines: A Narrative Review of Emerging Strategies and Clinical Prospects.Vaccines · 2025Review
- Chronic pain in older adults with psychiatric disorders: the DoCPPA study protocol.BMC geriatrics · 2025Article
- Cognitive Functioning in Females with Endometriosis-Associated Chronic Pelvic Pain: A Literature Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Review
- A programmable and self-adaptive ultrasonic wireless implant for personalized chronic pain management.Nature electronics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Acutely, pain is protective. It promotes escape from, and future avoidance of, noxious stimuli through strong and often lifetime associative memories. However, with persistent acute pain or when pain becomes chronic, these memories can promote negative emotions and poor decisions often associated with deleterious behaviors. In this review, we discuss how preclinical studies can provide insights into the relationship between cognition and chronic pain. We also discuss the concept of pain as a cognitive disorder and new strategies for treating chronic pain that emphasize inhibiting the formation of pain memories or promoting 'forgetting' of established pain memories.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.