ArticleAustralian critical care : official journal of the Confederation of Australian Critical Care Nurses2021
Complex and prolonged hypercoagulability in coronavirus disease 2019 intensive care unit patients: A thromboelastographic study.
Article in Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Acute pancreatitis induces a transient hypercoagulable state in murine models.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023Article
- Utility of Thromboelastography and velocity curve derivative in diagnosing COVID-19 associated coagulopathy.International journal of laboratory hematology · 2022Article
- Study of the Significance of Thromboelastography Changes in Patients with Dyslipidemia.Emergency medicine international · 2022Article
- Thromboelastography determined dynamics of blood coagulation and its correlation with complications and outcomes in patients with coronavirus disease 2019.Research and practice in thrombosis and haemostasis · 2022Article
- The evolution of clot strength in critically-ill COVID-19 patients: a prospective observational thromboelastography study.Thrombosis journal · 2021Article
- Viscoelastometric Testing to Assess Hemostasis of COVID-19: A Systematic Review.Journal of clinical medicine · 2021Review
- 2020 the year we wish never was.Australian critical care : official journal of the Confederation of Australian Critical Care Nurses · 2021Article
- Risk Management and Treatment of Coagulation Disorders Related to COVID-19 Infection.International journal of environmental research and public health · 2021Review
- Prevalence and Trajectory of COVID-19-Associated Hypercoagulability Using Serial Thromboelastography in a South African Population.Critical care research and practice · 2021Article
- Thromboelastographic insights into hemostatic alterations in coronavirus disease 2019 (COVID-19) patients.Asian journal of transfusion scienceArticle
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Authors and funding
13 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundA high number of thrombotic complications have been reported in critically ill patients with coronavirus disease 2019 (COVID-19) and appear to be related to a hypercoagulable state. Evidence regarding detection, management, and monitoring of COVID-19-associated coagulopathy is still missing. We propose to describe the thrombus viscoelastic properties to investigate the mechanisms of hypercoagulability in patients with COVID-19.
methodsThromboelastography (TEG) was performed in 24 consecutive patients admitted to a single intensive care unit for COVID-19 pneumonia, and 10 had a second TEG before being discharged alive from the intensive care unit.
resultsCompared with a group of 20 healthy participants, patients with COVID-19 had significantly decreased values of reaction time, coagulation time, and lysis index and increased values of α angle, maximum amplitude, clot strength, and coagulation index. Velocity curves were consistent with increased generation of thrombin. These values persisted in surviving patients despite their good clinical course. DISCUSSION: In patients with COVID-19, TEG demonstrates a complex and prolonged hypercoagulable state including fast initiation of coagulation and clot reinforcement, low fibrinolysis, high potential of thrombin generation, and high fibrinogen and platelet contribution. The antithrombotic strategy in patients with COVID-19 during intensive care hospitalisation and after discharge should be investigated in further studies.
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