ArticleBMC neurology2021
Guillain-Barré syndrome triggered by surgery in a Chinese population: a multicenter retrospective study.
Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- A rapid onset of Guillain-Barre syndrome following spinal anesthesia for knee arthroscopy: a case report.Journal of medical case reports · 2025Article
- Guillain-Barré syndrome in patients with multiple myeloma: three cases report and literature review.BMC neurology · 2025Review
- Recurrent Guillain-Barré Syndrome After Subsequent Total Knee Arthroplasties.Arthroplasty today · 2024Article
- Article
- Guillain-Barré syndrome after surgery: a literature review.Frontiers in neurology · 2024Review
- Guillain-Barré syndrome after percutaneous coronary intervention and transcatheter aortic valve implantation.Journal of cardiology cases · 2023Article
- Letter to the Editor: Guillain-Barré Syndrome Needs to Be Considered as a Cause of Idiopathic Bilateral Vocal Fold Paralysis.Journal of Korean medical science · 2022Article
- Guillain-Barre Syndrome following lower segment caesarean section under spinal anesthesia: A case report.Clinical case reports · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSurgery is a potential trigger of Guillain-Barré syndrome (GBS), a disorder which leads to an autoimmune-mediated attack of peripheral nerves. The present study was designed to explore clinical features of post-surgical GBS compared with those of general GBS in order to provide better clinical advice to patients undergoing surgery.
methodsThe medical records of GBS patients who were seen at 31 tertiary hospitals in southern China between January 1, 2013 and September 30, 2016 were retrospectively analyzed. Post-surgical GBS was defined as symptoms of GBS within 6 weeks after surgery. Clinical features of post-surgical GBS are described and are compared with general GBS.
resultsAmong the 1001 GBS patient cases examined in this study, 45 (4.5%) patient cases exhibited symptoms of GBS within 6 weeks of undergoing surgery. Within this group, 36 (80.0%) patients developed initial symptoms of limb weakness. The average interval between surgery and symptom onset was 13.31 days. The most common type of surgery which triggered GBS was orthopedic surgery, followed by neurological surgery. Compared to general GBS, post-surgical GBS was characterized by a higher proportion of severe patients (Hughes functional grading scale (HFGS) score ≥ 3) upon admission and at nadir, higher HFGS scores at discharge, and longer hospital stays. Post-surgical GBS patients also had a significantly higher frequency of the acute motor axonal neuropathy subtype (37.9 vs. 14.2, respectively; P = 0.001).
conclusionSurgery is probably a potential trigger factor for GBS, especially orthopedic surgery. Infections secondary to surgery may play a role. The possibility of preceding (post-operative) infections was not excluded in this study. Clinical presentation of post-surgical GBS is characterized by a more severe course and poorer prognosis, and should be closely monitored.
trial registrationchicTR-RRc-17,014,152 .
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