ArticleBMC cardiovascular disorders2021
The association between serum copper concentrations and elevated blood pressure in US children and adolescents: National Health and Nutrition Examination Survey 2011-2016.
Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Association between Serum Metal Levels and Blood Pressure in Aluminium Smelting Workers: Mediating Role of Gamma-Glutamyltransferase.Biological trace element research · 2026Article
- The Yin and Yang of copper in cardiovascular health and disease.Molecular and cellular biochemistry · 2026Review
- Association Between Serum Essential Metal Elements and Blood Pressure in Children: A Cohort Study.Cardiovascular toxicology · 2025Article
- Associations between modifiable risk factors and limitation in activities of daily living among individuals aged ≥ 45 years: Evidence from the China health and retirement longitudinal study (CHARLS).AIMS public health · 2025Article
- Plasma Copper and Metabolic Syndrome in Mesoamerican Children and Their Parents.Biological trace element research · 2024Article
- Association between omega-6 fatty acid intake and asthma in US children and adolescents.BMC pediatrics · 2024Article
- Association between copper intake and essential hypertension: dual evidence from Mendelian randomization analysis and the NHANES database.Frontiers in nutrition · 2024Article
- Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011-2014.Journal of cardiovascular development and disease · 2023Article
- Copper/Zinc Ratio in Childhood and Adolescence: A Review.Metabolites · 2023Review
- Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis.Nutrients · 2021Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCopper is an essential trace metal with potential interest for cardiovascular effects. Few studies have explored the association between copper and blood pressure in children and adolescents.
methodWe conducted a cross-sectional analysis of 1242 children and adolescents aged 8-17 years who participated in the 2011 to 2016 National Health and Nutrition Examination Survey. Using 2017 American Academy of Pediatrics guidelines, elevated blood pressure (EBP) was defined as a mean systolic and/or diastolic blood pressure (BP) ≥ 90th percentile for sex, age, and height for children aged 1-12 years and systolic BP ≥ 120 mmHg or diastolic BP ≥ 80 mmHg for adolescent age 13-17 years. Mean serum copper was 114.17 μg/dL.
resultsAfter multiple adjustments, dose-response analyses revealed that EBP was associated with progressively higher serum copper concentrations in a nonlinear trend. In comparison with the lowest quartile of serum copper concentrations, the adjusted odds of EBP for the highest quartile was 5.26 (95% confidence interval, 2.76-10.03).
conclusionOur results suggested that high serum copper concentrations were significantly associated with EBP in US children and adolescents.
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