ArticleAddiction biology2021
Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group.
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Article in Addiction biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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26citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 6% of its field
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Common and disorder-specific aberrant activation during reward and loss processing in major depressive disorder and addiction: a meta-analysis of fMRI studies.Molecular psychiatry · 2026Pooled it
- Substance use disorder and altered hemispheric asymmetries: A systematic review.Clinical psychology review · 2025Pooled it
- Measuring white matter microstructure in 1,457 cannabis users and 1,441 controls: A systematic review of diffusion-weighted MRI studies.Frontiers in neuroimaging · 2023Pooled it
- Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways.Addiction (Abingdon, England) · 2026Article
- Left and Right Hemispheric Lateralization as an Overlooked Variable in Psychiatric Disease: Evidence Across Species.Biological psychiatry · 2026Review
- Brain Structure and Substance Use: Disentangling Risk, Exposure, and Drug-Specific Effects.medRxiv : the preprint server for health sciences · 2026Article
- Effects of deep brain stimulation of the nucleus accumbens and anterior limb of the internal capsule on heroin addiction: Over five years of long-term follow-up in a prospective open-label pilot study.Translational psychiatry · 2025Article
- Looking at Both Sides: Integrating Data From Both Hemispheres Is Crucial in Rodent Neuroscience.The European journal of neuroscience · 2025Review
- Altered asymmetry of amygdala volume mediates food addiction and weight gain.Journal of behavioral addictions · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.medRxiv : the preprint server for health sciences · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.Frontiers in psychiatry · 2025Article
- Microstructural asymmetry in the human cortex.Nature communications · 2024Article
- Alterations of gray matter asymmetry in internet gaming disorder.Scientific reports · 2024Article
- Non-local diffusion-based biomarkers in patients with cocaine use disorder.Neuroimage. Reports · 2024Article
- White matter integrity of right frontostriatal circuit predicts internet addiction severity among internet gamers.Addiction biology · 2024Article
- Examination of reward processing dysfunctions in the left dorsal striatum and other brain regions among psychiatric inpatients with substance use.Drug and alcohol dependence · 2024Article
- Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children.Science advances · 2023Article
- Hemispheric asymmetries in mental disorders: evidence from rodent studies.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Recalibrating single-study effect sizes using hierarchical Bayesian models.Frontiers in neuroimaging · 2023Article
- NeuroBridge: a prototype platform for discovery of the long-tail neuroimaging data.Frontiers in neuroinformatics · 2023Article
Corrections and comments
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Authors and funding
36 authors at 20 institutions in 7 countries.
Zhipeng CaoDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA.ORCID 0000-0003-2624-2182
Jonatan Ottino-GonzalezDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA.
Renata B CupertinoDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA.
Nathan SchwabDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA.
Colin HokeDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA.
Orr CatherineDepartment of Psychological Sciences, School of Health Sciences, Swinburne University, Melbourne, Australia.
Janna CousijnDepartments of Psychology, University of Amsterdam, Amsterdam, Netherlands.
Alain DagherDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
John J FoxeDepartment of Neuroscience and The Ernest J. Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Anna E GoudriaanDepartment of Psychiatry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
Robert HesterMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Kent HutchisonDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.
Chiang-Shan R LiDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Edythe D LondonDavid Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-3577-7808
Valentina LorenzettiNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Sydney, Australia.
Maartje LuijtenBehavioural Science Institute, Radboud University, Nijmegen, Netherlands.
Rocio Martin-SantosDepartment of Psychiatry and Psychology, University of Barcelona, Barcelona, Spain.
Reza MomenanClinical NeuroImaging Research Core, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Martin P PaulusVA San Diego Healthcare System and Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
Lianne SchmaalOrygen, Parkville, Australia.
Rajita SinhaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Zsuzsika SjoerdsInstitute of Psychology and Leiden Institute for Brain and Cognition, Leiden University, Leiden, Netherlands.
Nadia SolowijSchool of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia.
Dan J SteinSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Elliot A SteinNeuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA.
Anne UhlmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Ruth J van HolstDepartment of Psychiatry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
Dick J VeltmanDepartment of Psychiatry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
Reinout W WiersAddiction Development and Psychopathology (ADAPT)-lab, Department of Psychology and Center for Urban Mental Health, University of Amsterdam, Amsterdam, Netherlands.
Murat YücelBrainPark, Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging Facility, Monash University, Melbourne, Victoria, Australia.
Sheng ZhangDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-5786-6516
Neda JahanshadMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, California, USA.
Paul M ThompsonImaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, Californis, USA.
Patricia ConrodDepartment of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montreal, Quebec, Canada.
Scott MackeyDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA.
Hugh GaravanDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA.
University of Vermont · USAmsterdam Neuroscience · NLYale University · USThe University of Melbourne · AUUniversity of Southern California · USAmsterdam Institute for Addiction Research · NLAmsterdam University of Applied Sciences · NLAustralian Catholic University · AUBarcelona Graduate School of Mathematics · ESLeiden University · NLMonash University · AUMontreal Neurological Institute and Hospital · CANational Institute on Alcohol Abuse and Alcoholism · USNational Institute on Drug Abuse · USRadboud University Nijmegen · NLSwinburne University of Technology · AUTechnische Universität Dresden · DEUniversité de Montréal · CAUniversity of California, Los Angeles · USUniversity of California San Diego · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MBrain Imaging of Human Drug AbuseZIADA000470 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI STEIN, ELLIOT A · 2009 to 2021
$15.8MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MChronic Alcohol and Brain Stress Circuit ResponseR01AA013892 · NIAAA · YALE UNIVERSITY · PI Rajita Sinha · 2003 to 2026
$10.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MENIGMA- Addiction: Pooling of Existing Datasets to Identify Brain and Genetic Correlates of Addiction, Next StepsR01DA047119 · NIDA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUGH P. GARAVAN · 2018 to 2026
$5.4MENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0MTrauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4MCognitive control and cocaine dependence: thalamic noradrenergic processesR01DA023248 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2008 to 2018
$4.0MProtocols, Statistics, Collaborative Method Development and ToolsPL1DA024859 · NIDA · YALE UNIVERSITY · PI SINHA, RAJITA · 2007 to 2011
$3.6MHigh resolution mapping of the genetic risk for disease in the aging brainR01AG059874 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA · 2018 to 2022
$3.1MENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5MNCATS NIH HHS UL1 TR001863NCRR NIH HHS UL1 RR024925NIAAA NIH HHS R01 AA013892NIAAA NIH HHS R01 AA021449NIA NIH HHS R01 AG059874NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIDA NIH HHS K25 DA040032NIDA NIH HHS PL1 DA024859NIDA NIH HHS PL30-1DA024859-01NIDA NIH HHS R01 DA014100NIDA NIH HHS R01 DA018307NIDA NIH HHS R01 DA020726NIDA NIH HHS R01 DA023248NIDA NIH HHS R01 DA047119NIDA NIH HHS R21 DA044749NIDA NIH HHS R21 DA045189NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH121246
Abstract
Brain asymmetry reflects left-right hemispheric differentiation, which is a quantitative brain phenotype that develops with age and can vary with psychiatric diagnoses. Previous studies have shown that substance dependence is associated with altered brain structure and function. However, it is unknown whether structural brain asymmetries are different in individuals with substance dependence compared with nondependent participants. Here, a mega-analysis was performed using a collection of 22 structural brain MRI datasets from the ENIGMA Addiction Working Group. Structural asymmetries of cortical and subcortical regions were compared between individuals who were dependent on alcohol, nicotine, cocaine, methamphetamine, or cannabis (n = 1,796) and nondependent participants (n = 996). Substance-general and substance-specific effects on structural asymmetry were examined using separate models. We found that substance dependence was significantly associated with differences in volume asymmetry of the nucleus accumbens (NAcc; less rightward; Cohen's d = 0.15). This effect was driven by differences from controls in individuals with alcohol dependence (less rightward; Cohen's d = 0.10) and nicotine dependence (less rightward; Cohen's d = 0.11). These findings suggest that disrupted structural asymmetry in the NAcc may be a characteristic of substance dependence.
Indexed as
AdultAlcoholismBehavior, AddictiveBrainBrain Cortical ThicknessCerebellar CortexFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingNucleus AccumbensSubstance-Related DisordersTobacco Use DisorderYoung Adultbrain asymmetrymega-analysissubstance dependence
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