ArticleAddiction biology2021
Impaired cognitive flexibility and heightened urgency are associated with increased alcohol consumption in rodent models of excessive drinking.
Article in Addiction biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Perceptual response patterns in rhesus macaque attentional set shifting are associated with inflexible behavior.Cognitive, affective & behavioral neuroscience · 2026Article
- Predicting alcohol consumption and reward sensitivity using responses for natural sucrose reward in non-food-restricted rats.Psychopharmacology · 2026Article
- Trail Making Test performance in early abstinence from methamphetamine: human evidence for a drug-associated Parkinsonian-like phenotype.Frontiers in psychiatry · 2026Article
- Disrupted decision making in adult male rats after prolonged withdrawal from ethanol vapor exposure.Alcohol, clinical & experimental research · 2025Article
- The null effect of stress on cognitive flexibility in individuals with and without alcohol use disorder.Drug and alcohol dependence · 2025Article
- Chronic Ethanol Exposure Produces Persistent Impairment in Cognitive Flexibility and Decision Signals in the Striatum.bioRxiv : the preprint server for biology · 2025Article
- Article
- Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility.Neuropharmacology · 2024Review
- Spontaneous flexibility, attentional set shifting and cognitive control in men with alcohol dependence.Postepy psychiatrii neurologii · 2024Article
- Impulsive Choices Emerge When the Anterior Cingulate Cortex Fails to Encode Deliberative Strategies.eNeuro · 2024Article
- Altered Structural Connectivity and Functional Brain Dynamics in Individuals With Heavy Alcohol Use Elucidated via Network Control Theory.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Proactive Versus Reactive Control Strategies Differentially Mediate Alcohol Drinking in Male Wistars and P Rats.eNeuro · 2024Article
- Distinct cortico-striatal compartments drive competition between adaptive and automatized behavior.PloS one · 2023Article
- Individual differences in behavioral flexibility predict future volitional ethanol consumption in mice.Alcohol (Fayetteville, N.Y.) · 2022Article
- Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and Survivability.Brain sciences · 2022Article
- Nitric Oxide Signaling Pathway in Ventral Tegmental Area is Involved in Regulation of 7,8-Dihydroxyflavone on Alcohol Consumption in Rats.Molecular neurobiology · 2022Article
- Serum cystatin C and cognitive function in midlife: results from the Hanzhong Adolescent Hypertension Study.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Alcohol use disorder (AUD) is characterized by impairments in decision-making that can exist as stable traits or transient states. Cognitive inflexibility reflects an inability to update information that guides decision-making and is thought to contribute to the inability to abstain from drinking. While several studies have reported evidence of impaired cognitive flexibility following chronic alcohol exposure, evidence that a pre-existing impairment in cognitive flexibility is a heritable risk factor for AUD is scarce. Here, we found that cognitive flexibility was impaired in rodents selectively bred for excessive alcohol consumption (alcohol preferring (P) rats), on the attentional set-shifting task (ASST). Further, the degree of impairment is predictive of future ethanol consumption, thus suggesting that cognitive inflexibility is a stable trait capable of predisposing one for drinking. In a second set of experiments, we observed an impairment in the ability of P rats to use a previously learned rule to guide foraging in a simple discrimination task. Convergence across several behavioral measures suggested that this impairment reflected a state of heightened urgency that interfered with decision-making. A similar impairment on a simple discrimination task was observed in Wistar rats with a history of alcohol consumption. These findings indicate how trait and state variables-in this case, impaired cognitive flexibility and heightened urgency, respectively-may influence the risk for excessive drinking. Furthermore, our results suggest that cognitive inflexibility and urgency can exist as both risk factors for and the result of alcohol exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.