Evidence map›Paper›PMID 33508854›Full record

ArticleNature2021

Cell competition constitutes a barrier for interspecies chimerism.

Canbin Zheng, Yingying Hu, Masahiro Sakurai, Carlos A Pinzon-Arteaga, Jie Li, Yulei Wei, Daiji Okamura, Benjamin Ravaux, Haley Rose Barlow, Leqian Yu and 4 more

Abstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The making of cells and organs in xenogeneic animal bioreactor.Signal transduction and targeted therapy · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Endocytic Control of Cell-Autonomous and Non-Cell-Autonomous Functions of p53.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Cell-Free DNA-Based Theranostics for Inflammatory Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Xenophagocytosis blockade enhances interspecies chimerism.bioRxiv : the preprint server for biology · 2025
    Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Canbin Zheng *Department of Microsurgery, Orthopaedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yingying Hu *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Masahiro Sakurai *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-6376-0299
Carlos A Pinzon-ArteagaDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-4906-6751
Jie LiBGI-Shenzhen, Shenzhen, China.
Yulei WeiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Daiji OkamuraDepartment of Advanced Bioscience, Graduate School of Agriculture, Kindai University, Nara, Japan.
Benjamin RavauxDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Haley Rose BarlowDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-3414-4574
Leqian YuDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hai-Xi SunBGI-Shenzhen, Shenzhen, China.
Elizabeth H ChenDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-2707-6083
Ying GuBGI-Shenzhen, Shenzhen, China.
Jun WuDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. jun2.wu@utsouthwestern.edu.ORCID http://orcid.org/0000-0001-9863-1668

Funding

Molecular Mechanisms of Myoblast FusionR01AR053173 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, ELIZABETH H · 2006 to 2022
$5.3M
Decoding the mechanisms of cell-cell fusion - Renewal - 1R35GM136316 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Elizabeth H Chen · 2020 to 2026
$3.1M
Dissecting the Mechanisms of Cell-Cell Fusion Using A Cell Culture SystemR01GM098816 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, ELIZABETH H · 2012 to 2019
$2.9M
NIAMS NIH HHS R01 AR053173NIGMS NIH HHS R01 GM098816NIGMS NIH HHS R35 GM136316
6 · The paper itself

Abstract

Cell competition involves a conserved fitness-sensing process during which fitter cells eliminate neighbouring less-fit but viable cells

Indexed as

ChimerismAnimalsCell CompetitionCell CountCell SurvivalCoculture TechniquesEmbryo, MammalianFemaleHumansMaleMiceMyeloid Differentiation Factor 88NF-kappa BPluripotent Stem CellsSignal TransductionSpecies SpecificityMYD88 protein, humanMyeloid Differentiation Factor 88NF-kappa BRELA protein, humanTranscription Factor RelA

Identifiers

PMID33508854
PMCPMC11163815

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.