Evidence map›Paper›PMID 33508739›Full record

ArticleAtencion primaria2021

Validation and psychometric properties of the 8-item Morisky Medication Adherence Scale (MMAS-8) in type 2 diabetes patients in Spain.

Pablo Martinez-Perez, Domingo Orozco-Beltrán, Francisco Pomares-Gomez, Juan L Hernández-Rizo, Anna Borras-Gallen, Vicente F Gil-Guillen, Jose A Quesada, Adriana Lopez-Pineda, Concepción Carratala-Munuera

2 registry-linked trialsAbstract read
In one paragraph

Article in Atencion primaria, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06117722 unknown statusnot on this mapstarted 2024, after this paper: background citation

ESTIA: TorasEmide Induced Effect on Quality of Life and Clinical parameterS in paTients With chronIc heArt Failure Receiving Eplerenone. Multicenter, Non-interventional, Prospective, Observational Clinical Study.

TypeobservationalSponsorElpen Pharmaceutical Co. Inc.Ran2024 to 2025Enrolled210ConditionsChronic Heart FailureArmsEplerenone torasemide in chronic heart failure
NCT07690397 phase4active not recruitingnot on this mapstarted 2026, after this paper: background citation

GLAUCO-TECH Study: Safety & Efficacy of Preservative-free vs. Preserved Dorzolamide-Timolol-Brimonidine. Impact on the Ocular Surface, Glaucoma Progression, Tear Proteomics, and AI/Chatbot-led Patient Follow-up.

TypeinterventionalSponsorTecnoquimicasRan2026 to 2027Enrolled140ConditionsPrimary Open-Angle Glaucoma (POAG), Ocular HypertensionArmsPreservative-free dorzolamide-timolol-brimonidine combination, Preservative dorzolamide-timolol-brimonidine combination
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pablo Martinez-PerezFamily Medicine Chair, Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain.
Domingo Orozco-BeltránFamily Medicine Chair, Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain.
Francisco Pomares-GomezEndocrinology Department, San Juan University Hospital, San Juan de Alicante, Spain.
Juan L Hernández-RizoFamily Medicine Chair, Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain.
Anna Borras-GallenPrimary Care Department, Hospital Marina Salud de Denia, Denia, Spain.
Vicente F Gil-GuillenFamily Medicine Chair, Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain.
Jose A QuesadaFamily Medicine Chair, Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain. Electronic address: jquesada@umh.es.
Adriana Lopez-PinedaFamily Medicine Chair, Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain.
Concepción Carratala-MunueraFamily Medicine Chair, Clinical Medicine Department, Miguel Hernandez University, San Juan de Alicante, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo validate a translated and culturally adapted version of the Morisky Medication Adherence Scale for use in Spanish population, and to examine the psychometric properties of this scale in patients with type 2 diabetes mellitus in Spain.

designThis cross-sectional study was conducted in a single university hospital in Spain. Patients diagnosed with type 2 diabetes mellitus at least 1 year before inclusion, being treated with anti-diabetic medication were included.

interventionWe used the Spanish version of the scale to measure treatment adherence. PRINCIPAL MEASUREMENTS: three level categorical scale is broken down into low adherence (score of <6), medium adherence (score of 6 to <8) and high adherence (score of 8). To validate the questionnaire, we measured internal consistency through Cronbach's α, confirmed construct validity through an exploratory principal component analysis and assessed test-retest reliability.

results232 patients met the inclusion criteria. The Cronbach's α coefficient was 0.40 (95% CI 0.28-0.52). The exploratory principal component analysis showed three components. The intraclass correlation coefficient was 0.718 (95% CI 0.564-0.823).

conclusionsthe Spanish version of the Morisky Medication Adherence scale showed low internal consistency, the exploratory factor analysis identified three dimensions, and the test-retest reliability was acceptable, therefore, psychometric properties of MMAS-8 are not suitable for measuring medication adherence in type 2 diabetes mellitus patients from Spain.

Indexed as

Diabetes Mellitus, Type 2Cross-Sectional StudiesHumansMedication AdherencePsychometricsReproducibility of ResultsSpainAdaptación transculturalAdherencia terapéuticaCross-cultural adaptationDiabetesEncuestas y cuestionariosMedication adherenceSurveys and questionnairesValidaciónValidation

Identifiers

PMID33508739
PMCPMC7844132

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.