ReviewCurrent opinion in neurobiology2021
Frozen algorithms: how the brain's wiring facilitates learning.
Review in Current opinion in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Recovery from disorders of consciousness: Lesions and GABAergic modulation in a biologically inspired spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The connectome of an insect brain.Science (New York, N.Y.) · 2023Article
- Training a spiking neuronal network model of visual-motor cortex to play a virtual racket-ball game using reinforcement learning.PloS one · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapses and neural connectivity are plastic and shaped by experience. But to what extent does connectivity itself influence the ability of a neural circuit to learn? Insights from optimization theory and AI shed light on how learning can be implemented in neural circuits. Though abstract in their nature, learning algorithms provide a principled set of hypotheses on the necessary ingredients for learning in neural circuits. These include the kinds of signals and circuit motifs that enable learning from experience, as well as an appreciation of the constraints that make learning challenging in a biological setting. Remarkably, some simple connectivity patterns can boost the efficiency of relatively crude learning rules, showing how the brain can use anatomy to compensate for the biological constraints of known synaptic plasticity mechanisms. Modern connectomics provides rich data for exploring this principle, and may reveal how brain connectivity is constrained by the requirement to learn efficiently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.