Evidence map›Paper›PMID 33508691›Full record

ArticleDrug and alcohol dependence2021

Heroin use is associated with liver fibrosis in the Miami Adult Studies on HIV (MASH) cohort.

Marianna K Baum, Javier A Tamargo, Richard L Ehman, Kenneth E Sherman, Jun Chen, Qingyun Liu, Raul N Mandler, Colby Teeman, Sabrina S Martinez, Adriana Campa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Marianna K BaumFlorida International University, Miami, FL, USA. Electronic address: baumm@fiu.edu.
Javier A TamargoFlorida International University, Miami, FL, USA. Electronic address: jtamargo@fiu.edu.
Richard L EhmanMayo Clinic, Rochester, MN, USA. Electronic address: ehman.richard@mayo.edu.
Kenneth E ShermanUniversity of Cincinnati, Cincinnati, OH, USA. Electronic address: kenneth.sherman@uc.edu.
Jun ChenMayo Clinic, Rochester, MN, USA. Electronic address: chen.jun@mayo.edu.
Qingyun LiuFlorida International University, Miami, FL, USA. Electronic address: qliu@fiu.edu.
Raul N MandlerNational Institute on Drug Abuse, Rockville, MD, USA. Electronic address: mandlerr@nida.nih.gov.
Colby TeemanFlorida International University, Miami, FL, USA. Electronic address: cteeman@fiu.edu.
Sabrina S MartinezFlorida International University, Miami, FL, USA. Electronic address: saless@fiu.edu.
Adriana CampaFlorida International University, Miami, FL, USA. Electronic address: campaa@fiu.edu.
Florida International University · USMayo Clinic in Arizona · USNational Institute on Drug Abuse · USUniversity of Cincinnati · US

Funding

Community-Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable PopulationsU01DA040381 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI BAUM, MARIANNA K · 2015 to 2022
$9.6M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
NIBIB NIH HHS R37 EB001981NIDA NIH HHS U01 DA040381
6 · The paper itself

Abstract

backgroundPeople who use opioids and people living with HIV (PLWH) are at increased risk for liver-related morbidity and mortality. Although animal models suggest that chronic opioid use may cause liver damage, research in humans is limited. We aimed to determine whether opioid use, particularly heroin, was associated with liver fibrosis.

methodsCross-sectional analysis of 679 participants (295 HIV/HCV uninfected, 218 HIV mono-infected, 87 HCV mono-infected, 79 HIV/HCV coinfected) from the Miami Adult Studies on HIV (MASH) cohort. Liver fibrosis was assessed via magnetic resonance elastography (MRE) on a 3 T Siemens MAGNETOM Prisma scanner.

resultsA total of 120 (17.7 %) participants used opioids. Liver fibrosis was present in 99 (14.6 %) participants and advanced liver fibrosis in 31 (4.6 %). Heroin use (N = 46, 6.8 %) was associated with HCV-seropositivity, smoking, misuse of prescription opioids, and polysubstance use. The use of heroin, but not misuse of prescription opioids, was significantly associated with liver fibrosis (OR = 2.77, 95 % CI: 1.18-6.50) compared to heroin non-users, after adjustment for confounders including excessive alcohol consumption, polysubstance use and HIV and HCV infections. Both HIV and HCV infections were associated with liver fibrosis, whether virally suppressed/undetectable or viremic.

conclusionsHeroin use was independently associated with increased risk for liver fibrosis irrespective of the use of other substances and HIV or HCV infections. Both HIV and HCV were associated with higher risk for liver fibrosis, even among those with suppressed or undetectable viral loads. The exact mechanisms for opioid-induced liver fibrosis remain to be fully elucidated.

Indexed as

AdultAnalgesics, OpioidCohort StudiesCross-Sectional StudiesFemaleFloridaHepatitis CHeroinHIV InfectionsHumansLiver CirrhosisMaleMiddle AgedOpioid-Related DisordersViral LoadAnalgesics, OpioidHeroinHepatitis CHIVLiver diseasesOpioidsSubstance abuse

Identifiers

PMID33508691
PMCPMC7889727
OpenAlexW3123324897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.