Evidence map›Paper›PMID 33508564›Full record

ArticleNeurobiology of aging2021

Locus coeruleus MRI contrast is associated with cortical thickness in older adults.

Shelby L Bachman, Martin J Dahl, Markus Werkle-Bergner, Sandra Düzel, Caroline Garcia Forlim, Ulman Lindenberger, Simone Kühn, Mara Mather

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Trial
  2. Daily heart rate variability biofeedback training decreases locus coeruleus MRI contrast in younger adults in a randomized clinical trial.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023
    Trial
  3. Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Atrophy links lower novelty-related locus coeruleus connectivity to cognitive decline in preclinical AD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shelby L BachmanDavis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany. Electronic address: sbachman@usc.edu.
Martin J DahlCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Markus Werkle-BergnerCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Sandra DüzelCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Caroline Garcia ForlimDepartment of Psychiatry and Psychotherapy, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Ulman LindenbergerCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, UK.
Simone KühnDepartment of Psychiatry and Psychotherapy, University Clinic Hamburg-Eppendorf, Hamburg, Germany; Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany.
Mara MatherDavis School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Funding

RESEARCH TRAINING IN GERONTOLOGYT32AG000037 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 1985 to 2026
$13.2M
The Impact of Emotional Regulation on Cognition in AgingR01AG025340 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MATHER, MARA · 2004 to 2021
$7.9M
NIA NIH HHS R01 AG025340NIA NIH HHS T32 AG000037
6 · The paper itself

Abstract

There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and a measure reflecting LC integrity in 229 older and 67 younger adults. Using a magnetic resonance imaging sequence which yields high signal intensity in the LC, we assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue. The FreeSurfer software suite was used to quantify cortical thickness. LC contrast was positively related to cortical thickness in older adults, and this association was prominent in parietal, frontal, and occipital regions. Brain regions where LC contrast was related to cortical thickness include portions of the frontoparietal network which have been implicated in noradrenergically modulated cognitive functions. These findings provide novel evidence for a link between LC structure and cortical brain structure in later adulthood.

Indexed as

Magnetic Resonance ImagingAdultAgedAged, 80 and overAge FactorsAgingAttentionCerebral CortexCognitionFemaleHumansLocus CoeruleusMaleMemoryMiddle AgedPonsAgingBrain structureCortical thicknessFrontoparietal networkLocus coeruleusNorepinephrine

Identifiers

PMID33508564
PMCPMC7920995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.