Evidence map›Paper›PMID 33508483›Full record

ArticleJournal of global antimicrobial resistance2021

Resistome of a carbapenemase-producing novel ST232 Klebsiella michiganensis isolate from urban hospital effluent in South Africa.

T L King, S Schmidt, S Thakur, P Fedorka-Cray, S Keelara, L Harden, S Y Essack

Open access · goldAbstract read
In one paragraph

Article in Journal of global antimicrobial resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Genomic characterisation and antimicrobial resistance ofFrontiers in cellular and infection microbiology · 2026
    Article
  2. Article
  3. Characterization of a Highly VirulentInfection and drug resistance · 2024
    Article
  4. Article
  5. Article
  6. A clinical KPC-producingFrontiers in microbiology · 2022
    Article
  7. Epidemiology ofInfection and drug resistance · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

T L KingDiscipline of Microbiology, University of KwaZulu-Natal, Pietermaritzburg, South Africa; Antimicrobial Research Unit, University of KwaZulu-Natal, Durban, South Africa.
S SchmidtDiscipline of Microbiology, University of KwaZulu-Natal, Pietermaritzburg, South Africa. Electronic address: schmidts@ukzn.ac.za.
S ThakurCentre for Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
P Fedorka-CrayCentre for Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
S KeelaraCentre for Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
L HardenCentre for Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
S Y EssackAntimicrobial Research Unit, University of KwaZulu-Natal, Durban, South Africa.
North Carolina State University · USUniversity of KwaZulu-Natal · ZA

Funding

Enhancing the whole genome sequence(WGS)based surveillance of Salmonella, Listeria and Shiga Toxin producing Escherichia coli(STEC) isolated from food and environment at the national and global levelU18FD006194 · FDA · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CRAY, PAULA, THAKUR, SIDDHARTHA · 2017 to 2018
$330k
FDA HHS U18 FD006194FDA HHS U19 FD007113
6 · The paper itself

Abstract

objectivesKlebsiella michiganensis is an emerging pathogen implicated in nosocomial infections. Here we report on the resistome, virulome and mobilome of a carbapenemase-producing K. michiganensis isolate from urban hospital effluent in Pietermaritzburg, KwaZulu-Natal, South Africa. Klebsiella sp. isolate KP124 was originally isolated from the final effluent of an urban tertiary hospital in Pietermaritzburg, KwaZulu-Natal.

methodsFollowing phenotypic characterisation and antibiotic susceptibility testing, the genome of carbapenemase-producing isolate KP124 was sequenced using an Illumina MiSeq platform, de novo assembled and analysed using established bioinformatics tools.

resultsThe draft genome of strain KP124 was 6 544 586 bp in length, comprising 203 contigs >200 bp. Following confirmation of isolate KP124 as K. michiganensis using reference genomes, the bla

conclusionThis study represents the first report of an OXA-181 carbapenemase-producing K. michiganensis isolate from hospital effluent in South Africa. The presence of such a strain in the environment owing to the absence of hospital effluent treatment presents a potential risk to informal communities that may use contaminated surface water domestically.

Indexed as

KlebsiellaBacterial Proteinsbeta-LactamasesDrug Resistance, BacterialHospitals, UrbanSouth AfricaBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemaseGenomeHospital effluentKlebsiella michiganensisSouth Africa

Identifiers

PMID33508483
PMCPMC8012231
OpenAlexW3123516664

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.