ArticleArchives of physical medicine and rehabilitation2021
Traumatic Spinal Cord Injury and Risk of Early and Late Onset Alzheimer's Disease and Related Dementia: Large Longitudinal Study.
Article in Archives of physical medicine and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Environmental and lifestyle risk factors for early-onset dementia: a systematic review.Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Effects of 30-Day Midodrine Administration, Compared to Placebo, on Blood Pressure, Cerebral Blood Flow Velocity, and Cognitive Performance in Persons with SCI.Topics in spinal cord injury rehabilitation · 2024Trial
- Comorbidities and health-care use prior to early-onset Alzheimer's disease: A population-based case-control study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.Nature neuroscience · 2026Article
- Barriers and Facilitators in Access to Care Among Adults With Traumatic Spinal Cord Injuries: A Qualitative Study Comparing VA and Commercial Insurance.Health services insights · 2026Article
- Improving current understanding of cognitive impairment in patients with a spinal cord injury: A UK-based clinician survey.The journal of spinal cord medicine · 2025Article
- Coupling of Low Frequency Hemodynamic Oscillations Between the Brain and Spinal Cord.Human brain mapping · 2025Article
- Sit-up test to assess orthostatic hypotension in individuals with spinal cord injury.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Observational
- Article
- The diagnostic and prognostic capability of artificial intelligence in spinal cord injury: A systematic review.Brain & spine · 2025Review
- Identifying Likely Incidents of Traumatic Spinal Cord Injury and Elevated Risk of Alzheimer's Disease and Related Dementia: Health Care Cost Institute Data.Topics in spinal cord injury rehabilitation · 2025Article
- Risk of Parkinson's disease in spinal cord injury: a nationwide cohort study in South Korea.Scientific reports · 2024Article
- Review
- Old age alters inflammation and autophagy signaling in the brain, leading to exacerbated neurological outcomes after spinal cord injury in male mice.Brain, behavior, and immunity · 2024Article
- Spinal cord injury disrupts plasma extracellular vesicles cargoes leading to neuroinflammation in the brain and neurological dysfunction in aged male mice.Brain, behavior, and immunity · 2024Article
- Neuromuscular electrical stimulation to combat cognitive aging in people with spinal cord injury: protocol for a single case experimental design study.BMC neurology · 2024Article
- Use of preventive service and potentially preventable hospitalization among American adults with disability: Longitudinal analysis of Traditional Medicare and commercial insurance.Preventive medicine reports · 2024Article
- Associations Between Neuroinflammation-Related Conditions and Alzheimer's Disease: A Study of US Insurance Claims Data.Journal of Alzheimer's disease : JAD · 2024Article
- Readmission Rates and Episode Costs for Alzheimer Disease and Related Dementias Across Hospitals in a Statewide Collaborative.JAMA network open · 2023Article
- Magnetic resonance spectroscopy investigation in the right human hippocampus following spinal cord injury.Frontiers in neurology · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTraumatic spinal cord injury (TSCI) is a life altering event most often causing permanent physical disability. Little is known about the risk of developing Alzheimer disease and related dementia (ADRD) among middle-aged and older adults living with TSCI. Time to diagnosis of and adjusted hazard for ADRD was assessed.
designCohort study.
settingUsing 2007-2017 claims data from the Optum Clinformatics Data Mart, we identified adults (45+) with diagnosis of TSCI (n=7019). Adults without TSCI diagnosis were included as comparators (n=916,516). Using age, sex, race/ethnicity, cardiometabolic, psychological, and musculoskeletal chronic conditions, US Census division, and socioeconomic variables, we propensity score matched persons with and without TSCI (n=6083). Incidence estimates of ADRD were compared at 4 years of enrollment. Survival models were used to quantify unadjusted, fully adjusted, and propensity-matched unadjusted and adjusted hazard ratios (HRs) for incident ADRD.
participantsAdults with and without TSCI (N=6083).
interventionNot applicable. MAIN OUTCOMES MEASURES: Diagnosis of ADRD.
resultsBoth middle-aged and older adults with TSCI had higher incident ADRD compared to those without TSCI (0.5% vs 0.2% and 11.7% vs 3.3% among 45-64 and 65+ y old unmatched cohorts, respectively) (0.5% vs 0.3% and 10.6% vs 6.2% among 45-64 and 65+ y old matched cohorts, respectively). Fully adjusted survival models indicated that adults with TSCI had a greater hazard for ADRD (among 45-64y old: unmatched HR: 3.19 [95% confidence interval, 95% CI, 2.30-4.44], matched HR: 1.93 [95% CI, 1.06-3.51]; among 65+ years old: unmatched HR: 1.90 [95% CI, 1.77-2.04], matched HR: 1.77 [1.55-2.02]).
conclusionsAdults with TSCI are at a heightened risk for ADRD. Improved clinical screening and early interventions aiming to preserve cognitive function are of paramount importance for this patient cohort.
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Registered trials
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