ArticlePLoS neglected tropical diseases2021
Severe hepatobiliary morbidity is associated with Clonorchis sinensis infection: The evidence from a cross-sectional community study.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Trial
- From infection to cholangiocarcinoma: Why opisthorchiids break these rules.One health (Amsterdam, Netherlands) · 2026Review
- A pathogenic CD8⁺ TNature communications · 2026Article
- Direct Choledochoscopic Visualization of LivingBalkan medical journal · 2026Article
- Schistosoma japonicum infection: clinical significance of ultrasound findings.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026Review
- Disability-adjusted life years of clonorchiasis in China: a high-resolution spatial analysis.Infectious diseases of poverty · 2025Article
- Research of the clinical features, risk factors, and surgical diagnosis of intramural stones in patients with gallbladder stones.Scientific reports · 2025Article
- Formation of non-cholesterol gallstones in populations within clonorchiasis endemic regions is closely related to Clonorchis sinensis infection.BMC gastroenterology · 2025Article
- Review
- The Brief Case: Incidental finding of a liver fluke following resection of hepatocellular carcinoma.Journal of clinical microbiology · 2025Review
- Relationship between mucin gene polymorphisms and different types of gallbladder stones.BMC medical genomics · 2025Article
- Article
- Current knowledge on the prevalence and detection techniques ofFrontiers in veterinary science · 2025Review
- Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control.Clinical microbiology reviews · 2024Review
- High-resolution mapping of age- and gender-specific risk of Clonorchis sinensis infection risk in Guangdong, China: a geostatistical modeling study.Parasites & vectors · 2024Article
- Foodborne Parasites and Their Complex Life Cycles Challenging Food Safety in Different Food Chains.Foods (Basel, Switzerland) · 2022Review
- Children education for sustainable control of liver fluke infections.Infectious diseases of poverty · 2022Article
- The Etiology of Cholelithiasis in Children and Adolescents-A Literature Review.International journal of molecular sciences · 2022Review
- Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex.PLoS neglected tropical diseases · 2022Article
- Cost yield of different treatment strategies against Clonorchis sinensis infection.Infectious diseases of poverty · 2021Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clonorchis sinensis infection is highly prevalent in Asia. Diverse hepatobiliary morbidity has been documented for C. sinensis infection. This study aimed to assess the association between C. sinensis infection and hepatobiliary morbidity, taking into consideration of the control, confounders and infection intensity. A cross-sectional community survey was implemented in Hengxian county, southeastern China. Helminth infections were detected by fecal examination. Physical examination and abdominal ultrasonography were then conducted. After excluding confounding effects from gender, age and alcohol drinking, quantitative association between C. sinensis infection and hepatobiliary morbidity was assessed, and the effect from infection intensity was also evaluated, through adjusted odds ratio (aOR) and 95% confidence intervals (95% CI). 696 villagers older than 10 years were enrolled. The prevalence and infection intensity of C. sinensis were higher in male, elder people and the individuals consuming alcohol. Light C. sinensis infection was associated with the increase of diarrhoea (aOR: 2.2, 95% CI: 1.1-4.5). C. sinensis infection was associated with the increase of fatty liver (aOR: 2.7, 95% CI: 1.4-5.2), and the effect was similar in different infection intensities. Moderate C. sinensis infection was associated with the increase of gallbladder stone (aOR: 3.0, 95% CI: 1.1-8.6), while moderate and heavy infections with the increase of intrahepatic bile duct dilatation (aOR: 2.2, 95% CI: 1.0-4.9 and aOR: 4.3, 95% CI: 1.9-9.9, respectively). C. sinensis infection had an effect on the development of periductal fibrosis (aOR: 3.2, 95% CI: 2.1-4.9), which showed increasing trend by infection intensity. The length and width of gallbladder in those with C. sinensis infection were enlarged, especially in those over 30 years old. C. sinensis infection is significantly associated with hepatobiliary morbidity. The occurrence of some morbidity was strongly related to the infection intensity. Awareness on harm of clonorchiasis should be raised both for policy-makers and villagers to adopt effective interventions.
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