ArticlePLoS neglected tropical diseases2021
Major risk factors and histopathological profile of treatment failure, relapse and chronic patients with anthroponotic cutaneous leishmaniasis: A prospective case-control study on treatment outcome and their medical importance.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Healing effects of autologous platelet gel and growth factors on cutaneous leishmaniasis wounds in addition to antimony; a self-controlled clinical trial with randomized lesion assignment.BMC research notes · 2023Trial
- Development of a predictive model for meglumine antimoniate treatment failure in patients with cutaneous leishmaniasis: Aretrospective cohort study.PLoS neglected tropical diseases · 2026Article
- Epidemiological patterns of cutaneous leishmaniasis in north-west Pakistan (2022-2023).BMC public health · 2025Article
- The developing role of NRF2 and HMOX1 in treatment response of cutaneous leishmaniasis.Scientific reports · 2025Article
- Unlocking Responsive and Unresponsive Signatures: A Transfer Learning Approach for Automated Classification in Cutaneous Leishmaniasis Lesions.Transboundary and emerging diseases · 2025Article
- An inclusive assessment of apoptosis mechanisms inCurrent research in parasitology & vector-borne diseases · 2025Review
- Preparation, Characterization, and Leishmanicidal Assessment of Silver- and Dapsone-Loaded Niosomes Co-administration:Advanced pharmaceutical bulletin · 2024Article
- Global Dilemma and Needs Assessment Toward Achieving Sustainable Development Goals in Controlling Leishmaniasis.Journal of epidemiology and global health · 2024Review
- Histological findings associated with treatment response in cutaneous leishmaniasis: a clinicopathological correlation study.International journal of dermatology · 2023Article
- Systematic Review of Treatment Failure and Clinical Relapses in Leishmaniasis from a Multifactorial Perspective: Clinical Aspects, Factors Associated with the Parasite and Host.Tropical medicine and infectious disease · 2023Review
- Clinical Profile and Diagnosis of Recurrent Cutaneous Leishmaniasis.Open forum infectious diseases · 2023Article
- Cutaneous leishmaniasis situation analysis in the Islamic Republic of Iran in preparation for an elimination plan.Frontiers in public health · 2023Review
- Geographical and climatic risk factors of cutaneous leishmaniasis in the hyper-endemic focus of Bam County in southeast Iran.Frontiers in public health · 2023Article
- Article
- Mutual Role of Patients and the Healthcare System in the Control of Cutaneous Leishmaniasis.Transboundary and emerging diseases · 2023Review
- Fifty years of struggle to control cutaneous leishmaniasis in the highest endemic county in Iran: A longitudinal observation inferred with interrupted time series model.PLoS neglected tropical diseases · 2022Article
- Cytotoxicity properties of plant-mediated synthesized K-doped ZnO nanostructures.Bioprocess and biosystems engineering · 2022Article
- The impact of diabetes on cutaneous leishmaniasis: a case-control field assessment.Parasitology research · 2021Article
- Early Leukocyte Responses inFrontiers in cellular and infection microbiology · 2021Article
- Determinants of Unresponsiveness to Treatment in Cutaneous Leishmaniasis: A Focus on Anthroponotic Form Due toFrontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last years, there has been a remarkable increase in the number of unresponsive patients with anthroponotic cutaneous leishmaniasis (ACL) reported worldwide. The primary objective of this study was to explore the role of demographic, clinical and environmental risk related-factors in the development of treatment failure, relapse and chronic cases compared to responsive patients with ACL. Moreover, molecular, histopathological and immunohistochemical (IHC) findings between these forms were explored. This work was undertaken as a prospective and case-control study in southeastern Iran. Culture media and nested PCR were used to identify the causative agent. Univariate multinomial and multiple multinomial logistic regression models and the backward elimination stepwise method were applied to analyze the data. A P<0.05 was defined as significant. Also, for different groups, skin punch biopsies were used to study the histopathological and immunohistochemical (IHC) profile. All samples showed that L. tropica was the only etiological agent in all unresponsive and responsive patients with ACL. Data analysis represented that 8 major risk factors including nationality, age groups, occupation, marital status, history of chronic diseases, duration of the lesion, the lesion on face and presence of domestic animals in the house were significantly associated with the induction of unresponsive forms. The histopathological and immunohistochemical findings were different from one form to another. The present findings clearly demonstrated a positive relation between ACL and distinct demographic, clinical and environmental risk determinants. Knowledge of the main risk factors for ACL infection is crucial in improving clinical and public health strategies and monitor such perplexing factors.
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