Evidence map›Paper›PMID 33507867›Full record

ReviewIEEE transactions on medical imaging2021

Multi-Site Infant Brain Segmentation Algorithms: The iSeg-2019 Challenge.

Yue Sun, Kun Gao, Zhengwang Wu, Guannan Li, Xiaopeng Zong, Zhihao Lei, Ying Wei, Jun Ma, Xiaoping Yang, Xue Feng and 25 more

Abstract readReview
In one paragraph

Review in IEEE transactions on medical imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Deep learning in fetal, infant, and toddler neuroimaging research.Developmental cognitive neuroscience · 2026
    Review
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  8. Article
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  14. Disentangled latent energy-based style translation: An image-level structural MRI harmonization framework.Neural networks : the official journal of the International Neural Network Society · 2025
    Article
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  16. Article
  17. Article
  18. Article
  19. MAPSeg: Unified Unsupervised Domain Adaptation for Heterogeneous Medical Image Segmentation Based on 3D Masked Autoencoding and Pseudo-Labeling.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Yue Sun
Kun Gao
Zhengwang Wu
Guannan Li
Xiaopeng Zong
Zhihao Lei
Ying Wei
Jun Ma
Xiaoping Yang
Xue Feng
Li Zhao
Trung Le Phan
Jitae Shin
Tao Zhong
Yu Zhang
Lequan Yu
Caizi Li
Ramesh Basnet
M Omair Ahmad
M N S Swamy
Wenao Ma
Qi Dou
Toan Duc Bui
Camilo Bermudez Noguera
Bennett Landman
Ian H Gotlib
Kathryn L Humphreys
Sarah Shultz
Longchuan Li
Sijie Niu
Weili Lin
Valerie Jewells
Dinggang Shen
Gang Li
Li Wang

Funding

The ontogeny of social vocal engagement and its derailment in autismP50MH100029 · NIMH · EMORY UNIVERSITY · PI KLIN, AMI · 2012 to 2021
$20.1M
Continued Development of Infant Brain Analysis ToolsR01MH117943 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG, WANG, LI · 2018 to 2022
$2.3M
Neuroimaging of the schizophrenia-associated 3q29 deletionR01MH118534 · NIMH · EMORY UNIVERSITY · PI MULLE, JENNIFER GLADYS, SHULTZ, SARAH · 2019 to 2023
$1.9M
Mapping the developing infant connectomeR01EB027147 · NIBIB · EMORY UNIVERSITY · PI CALHOUN, VINCE D, DAI, XIONGTAO · 2019 to 2022
$1.9M
Mapping the Infant Brain Developmental Connectome: Temporally Precise Growth Trajectories of Changing Infant Brain TopologyR01MH119251 · NIMH · EMORY UNIVERSITY · PI IRAJI, ARMIN, SHULTZ, SARAH · 2020 to 2023
$1.0M
Pathogenic insight into ASD from the study of neonatal brain-behavior transitionsK01MH108741 · NIMH · EMORY UNIVERSITY · PI SHULTZ, SARAH · 2016 to 2020
$857k
Volume-based Analysis of 6-month Infant Brain MRI for Autism Biomarker Identification and Early DiagnosisK01MH109773 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WANG, LI · 2017 to 2020
$571k
Effects of Environmental Stimulation and Nurturance on Neural and Endocrine Functions in InfantsR21HD090493 · NICHD · STANFORD UNIVERSITY · PI GOTLIB, IAN H · 2017 to 2018
$432k
The Role of Caregiver Social Processes on Neural and Endocrine Function in InfantsR21MH111978 · NIMH · STANFORD UNIVERSITY · PI GOTLIB, IAN H · 2017 to 2018
$432k
NIBIB NIH HHS R01 EB027147NICHD NIH HHS R21 HD090493NIMH NIH HHS K01 MH108741NIMH NIH HHS K01 MH109773NIMH NIH HHS P50 MH100029NIMH NIH HHS R01 MH117943NIMH NIH HHS R01 MH118534NIMH NIH HHS R01 MH119251NIMH NIH HHS R21 MH111978
6 · The paper itself

Abstract

To better understand early brain development in health and disorder, it is critical to accurately segment infant brain magnetic resonance (MR) images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF). Deep learning-based methods have achieved state-of-the-art performance; h owever, one of the major limitations is that the learning-based methods may suffer from the multi-site issue, that is, the models trained on a dataset from one site may not be applicable to the datasets acquired from other sites with different imaging protocols/scanners. To promote methodological development in the community, the iSeg-2019 challenge (http://iseg2019.web.unc.edu) provides a set of 6-month infant subjects from multiple sites with different protocols/scanners for the participating methods. T raining/validation subjects are from UNC (MAP) and testing subjects are from UNC/UMN (BCP), Stanford University, and Emory University. By the time of writing, there are 30 automatic segmentation methods participated in the iSeg-2019. In this article, 8 top-ranked methods were reviewed by detailing their pipelines/implementations, presenting experimental results, and evaluating performance across different sites in terms of whole brain, regions of interest, and gyral landmark curves. We further pointed out their limitations and possible directions for addressing the multi-site issue. We find that multi-site consistency is still an open issue. We hope that the multi-site dataset in the iSeg-2019 and this review article will attract more researchers to address the challenging and critical multi-site issue in practice.

Indexed as

AlgorithmsMagnetic Resonance ImagingBrainBrain MappingGray MatterHumansInfant

Identifiers

PMID33507867
PMCPMC8246057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.