ArticleThe American journal of sports medicine2021
Patient-Reported Outcomes and Knee Mechanics Correlate With Patellofemoral Deep Cartilage UTE-T2* 2 Years After Anterior Cruciate Ligament Reconstruction.
Article in The American journal of sports medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Molecular cartilage pathology following anterior cruciate ligament reconstruction: a systematic review of MRI studies.Frontiers in surgery · 2026Pooled it
- Clinical applications of UTE-T2* in knee MRI.Skeletal radiology · 2026Review
- Hip Joint Loading During Walking Is Associated With Cartilage Defect Severity in Young Adult Football Players With Hip/Groin Pain.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Early Imaging Biomarkers of Cartilage Strain After ACL Reconstruction Predict Patient Pain and Altered Knee Loading.Annals of biomedical engineering · 2026Article
- Use of hamstring autografts for ACL reconstruction significantly decreased the risk of reporting problems with kneeling at a 5-year follow-up.Journal of experimental orthopaedics · 2025Article
- MRI-derived articular cartilage strains predict patient-reported outcomes six months post anterior cruciate ligament reconstruction.Scientific reports · 2025Article
- Quantitative Ultrashort Echo Time Magnetization Transfer Imaging of the Osteochondral Junction: An In Vivo Knee Osteoarthritis Study.Journal of imaging · 2025Article
- Transformative approaches for effective clinical trials to reduce the disease burden of osteoarthritis.Seminars in arthritis and rheumatism · 2025Review
- Quantitative ultrashort echo time MR imaging of knee osteochondral junction: An ex vivo feasibility study.NMR in biomedicine · 2024Article
- Cartilage compositional MRI-a narrative review of technical development and clinical applications over the past three decades.Skeletal radiology · 2024Review
- Primary anterior cruciate ligament repair-morphological and quantitative assessment by 7-T MRI and clinical outcome after 1.5 years.European radiology · 2024Article
- Patellofemoral joint loading and early osteoarthritis after ACL reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Ultrashort echo time magnetic resonance imaging of the osteochondral junction.NMR in biomedicine · 2023Review
- Patellofemoral contact forces and knee gait mechanics 3 months after ACL reconstruction are associated with cartilage degradation 24 months after surgery.Osteoarthritis and cartilage · 2023Article
- Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects.Diagnostics (Basel, Switzerland) · 2022Review
- Preliminary study on the assessment of early cartilage degeneration by quantitative ultrashort echo time magnetic resonance imagingQuantitative imaging in medicine and surgery · 2022Article
- Effects of Male and Female Sex on the Development of Posttraumatic Osteoarthritis in the Porcine Knee After Anterior Cruciate Ligament Surgery.The American journal of sports medicine · 2022Article
- Application of Patient-Reported Outcome Measurements in Clinical Trials in China.JAMA network open · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPatellofemoral joint degeneration and dysfunction after anterior cruciate ligament reconstruction (ACLR) are increasingly recognized as contributors to poor clinical outcomes. PURPOSE: To determine if greater deep cartilage matrix disruption at 2 years after ACLR, as assessed by elevated patellofemoral magnetic resonance imaging (MRI) ultrashort echo time-enhanced T2* (UTE-T2*), is correlated with (1) worse patient-reported knee function and pain and (2) gait metrics related to patellofemoral tracking and loading, such as greater external rotation of the tibia at heel strike, reduced knee flexion moment (as a surrogate of quadriceps function), and greater knee flexion angle at heel strike. STUDY
designCross-sectional study; Level of evidence, 3.
methodsMRI UTE-T2* relaxation times in patellar and trochlear deep cartilage were compared with patient-reported outcomes and ambulatory gait metrics in 60 patients with ACLR at 2 years after reconstruction. ACLR gait metrics were compared with those of 60 uninjured reference patients matched by age, body mass index, and sex. ACLR UTE-T2* values were compared with those of 20 uninjured reference patients.
resultsHigher trochlear UTE-T2* values were associated with worse Knee injury and Osteoarthritis Outcome Scores (KOOS) Sport/Recreation subscale scores (rho = -0.32;
conclusionPatellofemoral deep cartilage matrix disruption, as assessed by MRI UTE-T2*, was associated with reduced sports and recreational function and with gait metrics reflective of altered patellofemoral loading. As such, the findings provide new mechanistic information important to improving clinical outcomes related to patellofemoral dysfunction after ACLR.
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Registered trials
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